Evidence map›Paper›PMID 33692748›Full record

ReviewFrontiers in neurology2021

The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge.

Iván Murrieta-Álvarez, Yahveth Cantero-Fortiz, Andrés A León-Peña, Juan C Olivares-Gazca, José Manuel Priesca-Marín, Guillermo J Ruiz-Delgado, Andrés Gómez-De-León, Elías Eugenio Gonzalez-Lopez, José Carlos Jaime-Pérez, David Gómez-Almaguer and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Multiple Sclerosis Care in Latin America.International journal of MS care · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Iván Murrieta-ÁlvarezCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
Yahveth Cantero-FortizCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
Andrés A León-PeñaCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
Juan C Olivares-GazcaCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
José Manuel Priesca-MarínCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
Guillermo J Ruiz-DelgadoCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
Andrés Gómez-De-LeónClínica Gómez Almaguer, Monterrey, Mexico.
Elías Eugenio Gonzalez-LopezClínica Gómez Almaguer, Monterrey, Mexico.
José Carlos Jaime-PérezHospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
David Gómez-AlmaguerClínica Gómez Almaguer, Monterrey, Mexico.
Guillermo J Ruiz-ArgüellesCentro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
Clínica Ruiz · MXBenemérita Universidad Autónoma de Puebla · MXHospital Universitario Dr José Eleuterio Gonzalez · MXUniversidad Popular Autónoma del Estado de Puebla · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After gaining experience conducting both auto and allografts in persons with hematological diseases in the HSCT programs in Puebla and Monterrey, México, this study outlines subsequent program autografting patients with autoimmune conditions. The first transplant in multiple sclerosis was conducted in Puebla on July 5, 2006. From 2015 we increased activity autografting persons with autoimmune conditions in the two campuses of the HSCT-México program: Puebla and Monterrey. By December 6, 2020, patient number 1,000 in the program was autografted. In our experience, a significant reduction in the expanded disability status scale score was achieved in all of the three phenotypes of the disease (from a median of 5.1 to 4.5 points), whereas the response rate (defined as a decrease of at least 0.5 of EDSS score regardless of baseline EDSS, or unchanged EDSS) was 83, 78, and 73% after 12 months in the relapsing-remitting, primary-progressive and secondary-progressive forms of multiple sclerosis, respectively. In addition to analyzing the viability, safety, and efficacy of our method, this study contributes new knowledge to the field of both stem cell transplantation and multiple sclerosis.

Indexed as

autoimmune diseasescyclophosphamideHSCTmultiple sclerosisnon-myeloablativeoutpatient carePBSCs

Identifiers

PMID33692748
PMCPMC7937693
OpenAlexW3131085023

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.