Evidence map›Paper›PMID 33692546›Full record

ArticleNature2021

Pattern-recognition receptors are required for NLR-mediated plant immunity.

Minhang Yuan, Zeyu Jiang, Guozhi Bi, Kinya Nomura, Menghui Liu, Yiping Wang, Boying Cai, Jian-Min Zhou, Sheng Yang He, Xiu-Fang Xin

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 570 papers.

0numbers the graph read from it
0cells of the map it votes in
570citing papers in PubMed
202.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

570 citing papers in PubMed, 1,131 citations in OpenAlex.

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  11. Proline Dehydrogenase GeneJournal of fungi (Basel, Switzerland) · 2026
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  19. Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026
    Review
  20. Article

510 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Minhang YuanNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Zeyu Jiang *National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Guozhi Bi *State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.
Kinya Nomura *Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.
Menghui LiuKey Laboratory of Plant Stress Biology, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng, China.
Yiping WangNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Boying CaiNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Jian-Min ZhouState Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-9943-2975
Sheng Yang HeDepartment of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.
Xiu-Fang XinNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China. xinxf@sippe.ac.cn.ORCID http://orcid.org/0000-0002-4037-3528
Chinese Academy of Sciences · CNCenter for Excellence in Molecular Plant Sciences · CNHenan University · CNHoward Hughes Medical Institute · USMichigan State University · US

Funding

Innate immunity-associated recycling endosome in Arabidopsis and pathogen attackR01GM109928 · NIGMS · MICHIGAN STATE UNIVERSITY · PI HE, SHENG YANG · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM109928
6 · The paper itself

Abstract

The plant immune system is fundamental for plant survival in natural ecosystems and for productivity in crop fields. Substantial evidence supports the prevailing notion that plants possess a two-tiered innate immune system, called pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). PTI is triggered by microbial patterns via cell surface-localized pattern-recognition receptors (PRRs), whereas ETI is activated by pathogen effector proteins via predominantly intracellularly localized receptors called nucleotide-binding, leucine-rich repeat receptors (NLRs)

Indexed as

ArabidopsisArabidopsis ProteinsNADPH OxidasesNLR ProteinsPlant DiseasesPlant ImmunityProtein Serine-Threonine KinasesPseudomonas syringaeReactive Oxygen SpeciesReceptors, Pattern RecognitionSignal TransductionArabidopsis ProteinsAT5G47910 protein, ArabidopsisBIK1 protein, ArabidopsisNADPH OxidasesNLR ProteinsProtein Serine-Threonine KinasesReactive Oxygen SpeciesReceptors, Pattern Recognition

Identifiers

PMID33692546
PMCPMC8016741
OpenAlexW3135339687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.