ArticleCommunications biology2021
Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Decoding the allosteric grammar of protein kinases: A dual-stream framework integrating protein language models and energy landscape frustration analysis.Protein science : a publication of the Protein Society · 2026Article
- Allosteric binding cooperativity in kinases signaling, signalopathies, and drug development.Current opinion in structural biology · 2025Review
- Structure and Dynamics of the Misfolding Intermediate in the Pathogenic T183A Prion Protein Mutant.Journal of chemical theory and computation · 2025Article
- Article
- Understanding ATP Binding to DosS Catalytic Domain with a Short ATP-Lid.Biochemistry · 2023Article
- AI-designed NMR spectroscopy RF pulses for fast acquisition at high and ultra-high magnetic fields.Nature communications · 2023Article
- Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors.ACS pharmacology & translational science · 2023Article
- An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP-dependent protein kinase A.FEBS letters · 2023Review
- Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma.Gastro hep advances · 2023Article
- Probing conformational landscapes and mechanisms of allosteric communication in the functional states of the ABL kinase domain using multiscale simulations and network-based mutational profiling of allosteric residue potentials.The Journal of chemical physics · 2022Article
- A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.Nature structural & molecular biology · 2022Article
- Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A framework for fibrolamellar carcinoma research and clinical trials.Nature reviews. Gastroenterology & hepatology · 2022Review
- Dynamic equilibria in protein kinases.Current opinion in structural biology · 2021Review
- Integrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A (Journal of proteome research · 2021Article
- GPharmacological reviews · 2021Review
- Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?Journal of molecular biology · 2021Article
- Identification and Validation of the Pyroptosis-Related Molecular Subtypes of Lung Adenocarcinoma by Bioinformatics and Machine Learning.Frontiers in cell and developmental biology · 2021Article
- Unbiased clustering of residues undergoing synchronous motions in proteins using NMR spin relaxation data.Biophysical chemistryArticle
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 5 institutions in 3 countries.
Cristina Olivieri *Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6957-6743
Caitlin Walker *Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-0977-8276
Adak Karamafrooz *Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Yingjie WangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
V S ManuDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Fernando PorcelliDIBAF - University of Tuscia - Largo dell' Università, Viterbo, Italy.ORCID http://orcid.org/0000-0003-3209-0074
Donald K BlumenthalDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-8614-1167
David D ThomasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-8822-2040
David A BernlohrDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6969-9129
Sanford M SimonLaboratory of Cellular Biophysics, Rockefeller University, New York, NY, USA.
Susan S TaylorDepartment of Chemistry and Biochemistry and Pharmacology, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7702-6108
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. vegli001@umn.edu.ORCID http://orcid.org/0000-0002-2795-6964
University of Minnesota · USRockefeller University · USUniversità degli Studi della Tuscia · ITUniversity of California San Diego · USUniversity of Utah · US
Funding
Project 4: ImmunovirotherapyP50CA210964 · NCI · MAYO CLINIC ROCHESTER · PI Zongming Eric Chen · 2018 to 2026
$20.5MLessons Learned from PKA: Assembly of Dynamic Macromolecular SwitchesR35GM130389 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN S. TAYLOR · 2019 to 2026
$5.7MWhat differences between the chimeric fusion oncoprotein DNAJB1-PRKACA and native kinase PRKACA lead to transformation in the childhood cancer, fibrolamellar hepatocellular carcinoma?U54CA243126 · NCI · ROCKEFELLER UNIVERSITY · PI SIMON, SANFORD M · 2019 to 2023
$5.4MStructural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2MSite-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5MMapping Allosteric Cooperativity in Protein KinasesR01GM100310 · NIGMS · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2012 to 2019
$4.3MProtein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2MConsole Upgrade for a 600 MHz NMR SpectrometerS10OD021536 · OD · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2016 to 2016
$850kNCI NIH HHS P50 CA210964NCI NIH HHS U54 CA243126NHLBI NIH HHS R01 HL139065NIA NIH HHS R01 AG026160NIA NIH HHS R37 AG026160NIGMS NIH HHS R01 GM100310NIGMS NIH HHS R35 GM130389NIH HHS S10 OD021536
Abstract
An aberrant fusion of the DNAJB1 and PRKACA genes generates a chimeric protein kinase (PKA-C
Indexed as
Adenosine TriphosphateAllosteric RegulationBinding SitesCatalytic DomainCyclic AMPCyclic AMP-Dependent Protein Kinase Catalytic SubunitsHSP40 Heat-Shock ProteinsHumansLigandsMolecular Dynamics SimulationPeptide FragmentsPhosphorylationProtein BindingRecombinant Fusion ProteinsAdenosine TriphosphateCyclic AMPCyclic AMP-Dependent Protein Kinase Catalytic SubunitsDNAJB1 protein, humanHSP40 Heat-Shock ProteinsLigandsPeptide FragmentsPRKACA protein, humanRecombinant Fusion Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.