SynthesisScientific reports2021
Accuracy and precision of the spinal instability neoplastic score (SINS) for predicting vertebral compression fractures after radiotherapy in spinal metastases: a meta-analysis.
Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Stereotactic body radiation therapy in elderly patients with spinal metastases.Journal of neuro-oncology · 2026Article
- Beyond SINS: A Critical Review of Biomechanical, Microstructural, and Radiomic Biomarkers for Predicting Fracture Risk in Spinal Metastases.Diagnostics (Basel, Switzerland) · 2026Review
- Cervical vertebral body metastasis from a gonadotroph pituitary neuroendocrine tumor: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- How to select a treatment method for patients with potentially unstable metastatic vertebrae (spinal instability neoplastic score 7-12): a systematic review.Asian spine journal · 2026Article
- Article
- Can Multi-Vertebral CT-Based Finite Element Models Accurately Predict Strains? An In Vitro Validation Study.International journal for numerical methods in biomedical engineering · 2025Article
- Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size.International journal for numerical methods in biomedical engineering · 2025Article
- Spinal Instability Neoplastic Score as a Predictor of Vertebral Fracture in Patients Undergoing Radiation Therapy for Spinal Metastases: A Single-Institution Study.Advances in radiation oncology · 2025Article
- Measuring the paraspinal muscles as an important tool for predicting the overall survival period after spine surgery in lung cancer patients with spine metastasis.BMC musculoskeletal disorders · 2025Article
- Prediction of vertebral failure under general loadings of compression, flexion, extension, and side-bending.Journal of the mechanical behavior of biomedical materials · 2025Article
- Surgical options for metastatic spine tumors: WFNS spine committee recommendations.Neurosurgical review · 2024Review
- Article
- Vertebral body collapse after radiotherapy for spinal metastases.Oncology letters · 2023Article
- Evaluation of Load-To-Strength Ratios in Metastatic Vertebrae and Comparison With Age- and Sex-Matched Healthy Individuals.Frontiers in bioengineering and biotechnology · 2022Article
- Review
- Changes in Spinal Instability After Conventional Radiotherapy for Painful Vertebral Bone Metastases.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy has played an important role in the treatment of spinal metastases. One of the major complications of radiotherapy is vertebral compression fracture (VCF). Although the spinal instability neoplastic score (SINS) was developed for evaluating spinal instability in patients with spinal metastases, it is also commonly used to predict VCF after radiotherapy in patients with spinal metastases. However, its accuracy for predicting radiotherapy-induced VCF and precision remain controversial. The aim of this study was to clarify the diagnostic value of the SINS to predict radiotherapy-induced VCF and to make recommendations for improving its diagnostic power. We searched core databases and identified 246 studies. Fourteen studies were analyzed, including 7 studies (with 1269 segments) for accuracy and 7 studies (with 280 patients) for precision. For accuracy, the area under the summary receiver operating characteristic curve was 0.776. When a SINS cut-off value of 7 was used, as was done in the included studies, the pooled sensitivity was 0.790 and the pooled specificity was 0.546. For precision, the summary estimate of interobserver agreement was the highest dividing 2 categories based on a cut-off value of 7, and the value was 0.788. The body collapse showed moderate relationship and precision with the VCF. The lytic tumor of bone lesion showed high accuracy and fair reliability, while location had excellent reliability, but low accuracy. The SINS system can be used to predict the occurrence of VCF after radiotherapy in spinal metastases with moderate accuracy and substantial reliability. Increasing the cut-off value and revising the domains may improve the diagnostic performance to predict the VCF of the SINS.
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