ArticleScientific reports2021
Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Novel High-Atomic-Number Element and Nanoparticle-Based CT Contrast Agents: Advanced Design Strategies and Clinical Translational Barriers.International journal of nanomedicine · 2026Review
- Assessment of CA4+ Impact on Mechanical Properties of Articular Cartilage.Materials (Basel, Switzerland) · 2025Article
- Dual-Contrast Agent with Nanoparticle and Molecular Components in Photon-Counting Computed Tomography: Assessing Articular Cartilage Health.Annals of biomedical engineering · 2025Article
- Photon-counting CT in cancer radiotherapy: technological advances and clinical benefits.Physics in medicine and biology · 2025Review
- Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage.Scientific reports · 2024Article
- Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study.Annals of biomedical engineering · 2024Article
- Chances and challenges of photon-counting CT in musculoskeletal imaging.Skeletal radiology · 2024Review
- Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints.Current osteoporosis reports · 2024Review
- Edge-illumination spectral phase-contrast tomography.Physics in medicine and biology · 2024Article
- Osteoarthritis year in review 2022: imaging.Osteoarthritis and cartilage · 2023Review
- Quantification of cartilage and subchondral bone cysts on knee specimens based on a spectral photon-counting computed tomography.Scientific reports · 2023Article
- Article
- Novel micro-MRI approach for subchondral trabecular bone analysis in patients with hip osteoarthritis is comparable to micro-CT approach.Croatian medical journal · 2022Article
- A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties.Diagnostics (Basel, Switzerland) · 2022Article
- Spectral Photon-Counting Computed Tomography: A Review on Technical Principles and Clinical Applications.Journal of imaging · 2022Review
- Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photon-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors that detects and sums the total energy from all photons during acquisition. The structure and composition of the articular cartilage cannot be detected with native CT imaging but can be assessed using contrast-enhancement. Spectral imaging allows simultaneous decomposition of multiple contrast agents, which can be used to target and highlight discrete cartilage properties. Here we report, for the first time, the use of PCD-CT to quantify a cationic iodinated CA4+ (targeting proteoglycans) and a non-ionic gadolinium-based gadoteridol (reflecting water content) contrast agents inside human osteochondral tissue (n = 53). We performed PCD-CT scanning at diffusion equilibrium and compared the results against reference data of biomechanical and optical density measurements, and Mankin scoring. PCD-CT enables simultaneous quantification of the two contrast agent concentrations inside cartilage and the results correlate with the structural and functional reference parameters. With improved soft tissue contrast and assessment of proteoglycan and water contents, PCD-CT with the dual contrast agent method is of potential use for the detection and monitoring of osteoarthritis.
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Registered trials
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