Evidence map›Paper›PMID 33692354›Full record

ArticleNature communications2021

Metamaterial assisted illumination nanoscopy via random super-resolution speckles.

Yeon Ui Lee, Junxiang Zhao, Qian Ma, Larousse Khosravi Khorashad, Clara Posner, Guangru Li, G Bimananda M Wisna, Zachary Burns, Jin Zhang, Zhaowei Liu

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Hyperbolic polariton-coupled emission optical microscopy.Nanophotonics (Berlin, Germany) · 2025
    Article
  8. Article
  9. Article
  10. Planar device-enabled speckle illumination for dark-field label-free imaging beyond the diffraction limit.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Metamaterial-Assisted Illumination Nanoscopy with Exceptional Axial Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Biomedical optics express · 2024
    Article
  13. Cascaded momentum-space polarization filters enabled label-free black-field microscopy for single nanoparticles analysis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Microscopies Enabled by Photonic Metamaterials.Sensors (Basel, Switzerland) · 2022
    Review
  20. Organic Hyperbolic Material Assisted Illumination Nanoscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yeon Ui Lee *Department of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA.ORCID 0000-0001-8857-1251
Junxiang Zhao *Department of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA.
Qian Ma *Department of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA.
Larousse Khosravi KhorashadDepartment of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA.ORCID 0000-0003-0461-5638
Clara PosnerDepartment of Pharmacology, University of California San Diego, San Diego, CA, 92093, USA.ORCID 0000-0002-0734-7686
Guangru LiDepartment of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA.
G Bimananda M WisnaMaterial Science and Engineering Program, University of California, San Diego, CA, 92093, USA.
Zachary BurnsDepartment of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA.
Jin ZhangDepartment of Pharmacology, University of California San Diego, San Diego, CA, 92093, USA.ORCID 0000-0001-7145-7823
Zhaowei LiuDepartment of Electrical and Computer Engineering, University of California, San Diego, CA, 92093, USA. zhaowei@ucsd.edu.ORCID 0000-0002-5732-8109

Funding

Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2M
MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
NCI NIH HHS R35 CA197622NIGMS NIH HHS T32 GM008326
6 · The paper itself

Abstract

Structured illumination microscopy (SIM) is one of the most powerful and versatile optical super-resolution techniques. Compared with other super-resolution methods, SIM has shown its unique advantages in wide-field imaging with high temporal resolution and low photon damage. However, traditional SIM only has about 2 times spatial resolution improvement compared to the diffraction limit. In this work, we propose and experimentally demonstrate an easily-implemented, low-cost method to extend the resolution of SIM, named speckle metamaterial-assisted illumination nanoscopy (speckle-MAIN). A metamaterial structure is introduced to generate speckle-like sub-diffraction-limit illumination patterns in the near field with improved spatial frequency. Such patterns, similar to traditional SIM, are then used to excite objects on top of the surface. We demonstrate that speckle-MAIN can bring the resolution down to 40 nm and beyond. Speckle-MAIN represents a new route for super-resolution, which may lead to important applications in bio-imaging and surface characterization.

Indexed as

Imaging, Three-DimensionalMicroscopyMicroscopy, Fluorescence

Identifiers

PMID33692354
PMCPMC7946936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.