Evidence map›Paper›PMID 33692213›Full record

ArticleJournal of virology2021

Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected

Ichiro Misumi, Zhucui Li, Lu Sun, Anshuman Das, Tomoyuki Shiota, John Cullen, Qibin Zhang, Jason K Whitmire, Stanley M Lemon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ichiro MisumiDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Zhucui LiUNCG Center for Translational Biomedical Research, North Carolina Research Campus, Kannapolis, North Carolina, USA.
Lu SunLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Anshuman DasLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Tomoyuki ShiotaLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
John CullenCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Qibin ZhangUNCG Center for Translational Biomedical Research, North Carolina Research Campus, Kannapolis, North Carolina, USA.
Jason K WhitmireDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stanley M LemonLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1450-806X
University of North Carolina at Chapel Hill · USDavid H. Murdock Research Institute · USNorth Carolina State University · USUniversity of North Carolina at Greensboro · US

Funding

Membrane Hijacking: Biogenesis and Fate of Quasi-Enveloped HepatovirusR01AI103083 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M. · 2012 to 2021
$4.0M
Critical Lipid Species in the Hepatovirus LifecycleR01AI150095 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M. · 2020 to 2024
$2.6M
Murine Model of Human Hepatitis AR01AI131685 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M., WHITMIRE, JASON KYLE · 2017 to 2021
$1.9M
Lipidome Remodeling During Development of T1DR01DK123499 · NIDDK · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI ZHANG, QIBIN · 2020 to 2024
$1.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI103083HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI131685HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI150095HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK123499NIAID NIH HHS R01 AI103083NIAID NIH HHS R01 AI131685NIAID NIH HHS R01 AI150095NIDDK NIH HHS R01 DK123499
6 · The paper itself

Abstract

Iminosugar compounds are monosaccharide mimetics with broad but generally weak antiviral activities related to inhibition of enzymes involved in glycobiology. Miglustat (

Indexed as

GangliosidesGlycoside Hydrolase InhibitorsHepatitis A1-Deoxynojirimycinalpha-GlucosidasesAnimalsAnti-Inflammatory AgentsAntiviral AgentsHepatitis A virusInflammationMiceMice, KnockoutReceptor, Interferon alpha-betaReceptors, InterferonVirus Internalization1-Deoxynojirimycinalpha-GlucosidasesAnti-Inflammatory AgentsAntiviral AgentsGangliosidesGlycoside Hydrolase InhibitorsIfnar1 protein, mousemiglustatN-9-methoxynonyldeoxynojirimycinReceptor, Interferon alpha-betaReceptors, Interferonantiviral agentsgangliosidehepatitis A virushost responseiminosugarliver immunologymiglustatpicornavirus

Identifiers

PMID33692213
PMCPMC9248035
OpenAlexW3134228924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.