ArticleScience advances2021
Robust information routing by dorsal subiculum neurons.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 90 citations in OpenAlex.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Shallow recurrent decoders for neural and behavioural dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Subicular spatial codes arise from predictive mapping.Nature communications · 2026Article
- Subicular plateaus signal reward locations during goal-directed behavior.Cell reports · 2026Article
- Article
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Response dynamics of discrete subiculum→retrosplenial cortex projections underlying trace fear conditioning.iScience · 2026Article
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- Topographic CA1 input shapes subicular spatial coding.bioRxiv : the preprint server for biology · 2026Article
- Article
- (Remembering) Vector Coding of Boundaries and Objects in the Subiculum.Hippocampus · 2026Review
- Non-Canonical Subiculum Circuit Organization and Function.Hippocampus · 2026Review
- Subicular Plateaus Signal Reward Locations during Goal-Directed Behavior.bioRxiv : the preprint server for biology · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- A molecularly anchored spatial transcriptomic framework for precise CA1-subiculum parcellation and region-resolved analysis in Alzheimer's disease.GigaScience · 2026Article
- Deep brain stimulation of the anterior nucleus of the thalamus in animal models of mesial temporal lobe epilepsy: A literature review.Epilepsy research · 2025Review
- Hippocampal neural circuit mechanisms in Alzheimer's disease revealed by viral-genetic circuit mapping.Neurobiology of disease · 2025Review
- A dorsal subiculum-medial mammillary body pathway for spatial memory.Molecular psychiatry · 2025Article
- Impairments of spatial memory retrieval via medial mammillary body dysfunction in Alzheimer's disease model.Translational psychiatry · 2025Article
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsal hippocampus conveys various information associated with spatial navigation; however, how the information is distributed to multiple downstream areas remains unknown. We investigated this by identifying axonal projections using optogenetics during large-scale recordings from the rat subiculum, the major hippocampal output structure. Subicular neurons demonstrated a noise-resistant representation of place, speed, and trajectory, which was as accurate as or even more accurate than that of hippocampal CA1 neurons. Speed- and trajectory-dependent firings were most prominent in neurons projecting to the retrosplenial cortex and nucleus accumbens, respectively. Place-related firing was uniformly observed in neurons targeting the retrosplenial cortex, nucleus accumbens, anteroventral thalamus, and medial mammillary body. Theta oscillations and sharp-wave/ripples tightly controlled the firing of projection neurons in a target region-specific manner. In conclusion, the dorsal subiculum robustly routes diverse navigation-associated information to downstream areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.