ArticleBMJ case reports2021
Severe vitamin deficiencies in pregnancy complicated by progressive familial intrahepatic cholestasis.
Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Earlier diagnosis of intrahepatic cholestasis of pregnancy and adverse pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- Adverse Outcomes Associated with Progressive Intrahepatic Cholestasis of Pregnancy.American journal of perinatology · 2025Article
- Simplifying Management of Cholestasis: A Proposal for a Classification System.American journal of perinatology · 2025Review
- Electrolyte imbalance and liver function test abnormalities among pregnant women with hyperemesis gravidarum at Wag-himra zone public hospitals, Northeast Ethiopia, 2023: a comparative cross-sectional study.Frontiers in medicine · 2024Article
- Severe cholestasis-associated coagulopathy diagnosed by routine screening: a case report.AJOG global reports · 2023Article
- Severe fat-soluble vitamin deficiency suspected secondary to intrahepatic cholestasis of pregnancy: A case report.Case reports in women's health · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progressive familial intrahepatic cholestasis (PFIC) is a rare disease of impaired bile acid excretion which can lead to nutritional deficiencies. Vitamin deficiencies during pregnancy can result in adverse maternal and fetal outcomes. A 20-year-old primiparous woman at 30 4/7 weeks with PFIC type 2 presented with worsening cholestasis, coagulopathy and fat-soluble vitamin deficiency. She developed visual deficits and was found to have severe vitamin A deficiency. Her coagulopathy and visual deficits improved following vitamin K and A supplementation, respectively. She delivered at 32 2/7 weeks following preterm labour. This case highlights several unique aspects in the care of pregnant women with liver disease. These patients are at risk for fat-soluble vitamin deficiencies which can result in significant coagulopathy and rarely, visual deficits due to vitamin A deficiency. Prompt treatment is necessary to prevent permanent sequelae.
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