Evidence map›Paper›PMID 33691774›Full record

ArticleBiology of sex differences2021

Sex differences in fetal Doppler parameters during gestation.

Dakshita Jagota, Hannah George, Melissa Walker, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L Whitehead, Sebastian R Hobson, Lena Serghides, W Tony Parks and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. The Placenta's Role in Sexually Dimorphic Fetal Growth Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Dakshita JagotaDepartment of Chemistry, Memorial University of Newfoundland, 283 Prince Philip Drive, St. John's, NL, A1B 3X7, Canada.
Hannah GeorgeDepartment of Chemistry, Memorial University of Newfoundland, 283 Prince Philip Drive, St. John's, NL, A1B 3X7, Canada.
Melissa WalkerMount Sinai Hospital, Toronto, Ontario, Canada.
Anjana Ravi ChandranMount Sinai Hospital, Toronto, Ontario, Canada.
Natasha MilliganDivision of Cardiology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Shiri ShinarMount Sinai Hospital, Toronto, Ontario, Canada.
Clare L WhiteheadPregnancy Research Centre, Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, Australia.
Sebastian R HobsonMount Sinai Hospital, Toronto, Ontario, Canada.
Lena SerghidesToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
W Tony ParksDepartment of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Ahmet A BaschatCentre for Fetal Therapy, Johns Hopkins Medicine, Baltimore, MD, USA.
Christopher K MacgowanTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
John G SledDepartment of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
John C KingdomMount Sinai Hospital, Toronto, Ontario, Canada.
Lindsay S CahillDepartment of Chemistry, Memorial University of Newfoundland, 283 Prince Philip Drive, St. John's, NL, A1B 3X7, Canada. lcahill@mun.ca.ORCID 0000-0003-1667-8564
Mount Sinai Hospital · CAMemorial University of Newfoundland · CAUniversity of Toronto · CAHospital for Sick Children · CAJohns Hopkins University · USRoyal Women's Hospital · AUUniversity Health Network · CA

Funding

Environmental factors in placental pathology: a new diagnostic method based on umbilical vessel wave mechanicsU01HD087177 · NICHD · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI SLED, JOHN G · 2015 to 2015
$2.5M
Eunice Kennedy Shriver National Institute of Child Health and Human Development U01-087177-01NICHD NIH HHS U01 HD087177
6 · The paper itself

Abstract

backgroundFetal sex is known to affect pregnancy outcomes. In current clinical practice, monitoring of fetal well-being is based on Doppler ultrasound measurements of major placental and fetal vessels. The objective of this study was to investigate the effect of fetal sex on Doppler parameters throughout gestation in healthy pregnancy.

methodsA prospective study was conducted in 240 pregnant women with ultrasound examinations at a 4-weekly interval between 12 and 38 weeks of gestation. Pulsed Doppler spectra were collected for the umbilical arteries (UAs), middle cerebral artery (MCA), descending abdominal aorta (DAo), and ductus venosus (DV). Linear mixed effects models were used to determine if the pulsatility indices (PIs) of these vessels depended on gestational age and fetal sex.

resultsWhile there were no differences in the MCA PI and DV PIV over gestation between female and male fetuses, the trajectory of the UA and DAo PIs differed by fetal sex (p = 0.02 and p = 0.01, respectively).

conclusionsDoppler ultrasound parameters were found to be dependent on fetal sex for some vessels and not for others in healthy pregnancies. Further investigations are needed to understand the physiological mechanisms for these sex differences and the relevance for disease processes in pregnancy.

Indexed as

Sex CharacteristicsUltrasonography, PrenatalFemaleHumansMalePlacentaPregnancyProspective StudiesUltrasonography, DopplerDoppler ultrasoundFetal sexPregnancyPulsatility indexSex differences

Identifiers

PMID33691774
PMCPMC7944891
OpenAlexW3135144428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.