SynthesisCritical care (London, England)2021
Systematic review of cognitive impairment and brain insult after mechanical ventilation.
Synthesis in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Using machine learning methods to predict 28-day mortality in patients with hepatic encephalopathy.BMC gastroenterology · 2023Trial
- Mechanical Ventilation-Associated Changes in Hippocampal Electroencephalogram: A Cross-Species Study in Humans and Rats.CNS neuroscience & therapeutics · 2026Article
- COVID-19 infections and cognitive impairment: mechanisms and perspectives.Breathe (Sheffield, England) · 2026Article
- Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents.Brain and behavior · 2026Review
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Rethinking Mechanical Ventilation: Can Ventilation Mode Influence Long-Term Cognitive Outcomes in ICU Patients with COVID-19?Journal of clinical medicine · 2026Article
- Understanding the influence of temporary neurologic dysfunction in the outcomes of aortic surgery.JTCVS open · 2025Article
- Phrenic stimulation decreases brain injury biomarkers in sedated mechanically ventilated patients: preliminary observations.Critical care (London, England) · 2025Article
- Effects of Anxiety Focused Nursing Interventions on Anxiety, Cognitive Function and Delirium in Neurocritical Patients: A Non-Randomized Controlled Design.Nursing in critical care · 2025Article
- Diaphragm Pacing in Early Critical Illness? A Plea for a Super-Relaxed Approach.American journal of respiratory and critical care medicine · 2025Article
- Lung-Brain Axis-Generated Inflammatory Biomarkers in Traumatic Brain Injury and Acute Respiratory Distress Syndrome: Role of Mechanical Ventilation/Stress.Advances in biomarker sciences and technology · 2025Article
- Posttraumatic stress disorder neurophysiology and clinical correlates in pediatric critical care: conceptualizing a PICU-PTSD framework.Frontiers in pediatrics · 2025Review
- Organ crosstalk: brain-lung interaction.Frontiers in medicine · 2025Review
- Effect of different ventilation modes on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic abdominal wall herniorrhaphy.International journal of clinical and experimental pathology · 2025Article
- Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.American journal of respiratory and critical care medicine · 2024Article
- Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation.American journal of respiratory and critical care medicine · 2024Article
- Phrenic Nerve Stimulation for Acute Respiratory Failure.Respiratory care · 2023Article
- A randomized, clinical trial investigating the use of a digital intervention to reduce delirium-associated agitation.NPJ digital medicine · 2023Article
- Diaphragm Neurostimulation Assisted Ventilation in Critically Ill Patients.American journal of respiratory and critical care medicine · 2023Review
- Future directions in ventilator-induced lung injury associated cognitive impairment: a new sight.Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a systematic review following the PRISMA protocol primarily to identify publications that assessed any links between mechanical ventilation (MV) and either cognitive impairment or brain insult, independent of underlying medical conditions. Secondary objectives were to identify possible gaps in the literature that can be used to inform future studies and move toward a better understanding of this complex problem. The preclinical literature suggests that MV is associated with neuroinflammation, cognitive impairment, and brain insult, reporting higher neuroinflammatory markers, greater evidence of brain injury markers, and lower cognitive scores in subjects that were ventilated longer, compared to those ventilated less, and to never-ventilated subjects. The clinical literature suggests an association between MV and delirium, and that delirium in mechanically ventilated patients may be associated with greater likelihood of long-term cognitive impairment; our systematic review found no clinical study that demonstrated a causal link between MV, cognitive dysfunction, and brain insult. More studies should be designed to investigate ventilation-induced brain injury pathways as well as any causative linkage between MV, cognitive impairment, and brain insult.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.