Evidence map›Paper›PMID 33691649›Full record

ArticleBMC ophthalmology2021

Analysis of structural injury patterns in peripapillary retinal nerve fibre layer and retinal ganglion cell layer in ethambutol-induced optic neuropathy.

Wen-Yan Sheng, Ling-Ya Su, Wei Ge, Shuang-Qing Wu, Li-Wei Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Delayed and reversible ethambutol optic neuropathy.American journal of ophthalmology case reports · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wen-Yan ShengDepartment of Ophthalmology, Zhejiang Hospital of Intergrated Traditional Chinese and Western Medicine, 208 Huancheng Road East, Zhejiang, 310003, Hangzhou, People's Republic of China.ORCID https://orcid.org/0000-0001-6903-0185
Ling-Ya SuDepartment of Ophthalmology, Zhejiang Hospital of Intergrated Traditional Chinese and Western Medicine, 208 Huancheng Road East, Zhejiang, 310003, Hangzhou, People's Republic of China.ORCID https://orcid.org/0000-0002-4600-2154
Wei GeDepartment of Ophthalmology, Zhejiang Hospital of Intergrated Traditional Chinese and Western Medicine, 208 Huancheng Road East, Zhejiang, 310003, Hangzhou, People's Republic of China.ORCID https://orcid.org/0000-0002-1078-5900
Shuang-Qing WuDepartment of Ophthalmology, Zhejiang Hospital of Intergrated Traditional Chinese and Western Medicine, 208 Huancheng Road East, Zhejiang, 310003, Hangzhou, People's Republic of China. shuangqingwu@zju.edu.cn.ORCID https://orcid.org/0000-0002-6766-4106
Li-Wei ZhuDepartment of Ophthalmology, Zhejiang Hospital of Intergrated Traditional Chinese and Western Medicine, 208 Huancheng Road East, Zhejiang, 310003, Hangzhou, People's Republic of China.
Zhejiang Hospital · CN

Funding

Hangzhou Science and Technology Bureau 20191203B129Hangzhou Science and Technology Development Projects 20170533B70
6 · The paper itself

Abstract

backgroundWe investigated structural injury patterns in the peripapillary retinal nerve fibre layer (p-RNFL) and ganglion cell inner plexiform layer (GCIPL) caused by ethambutol treatment.

methodsSixty-four patients undergoing ethambutol treatment at Zhejiang Chinese Medicine and Western Medicine Integrated Hospital were recruited. Fourteen (14) exhibited visual dysfunction (abnormal group), and the remaining 50 had no visual dysfunction (subclinical group). The thickness of the p-RNFL, total macular retina layer and GCIPL were measured using Cirrus-HD Optical coherence tomography (Cirrus-HD OCT, Cirrus high-definition optical coherence tomography), and compared with 60 healthy, age-matched controls.

resultsThe p-RNFL thickness was similar in both subclinical and control groups. When compared with the control group, p-RNFL thickness in the abnormal group was significantly increased in the inferior and superior quadrants (GEE, P = 0.040, P = 0.010 respectively). In contrast with the subclinical group, p-RNFL thickness in the inferior quadrant was increased in the abnormal group (GEE, P = 0.047). The GCIPL thickness in the inferonasal and inferior sectors was significantly deceased in the subclinical group when compared with controls (GEE, P = 0.028, P = 0.047, respectively). The average and minimum value of GCIPL thickness, and thickness in the superonasal, inferior, inferotemporal, superotemporal and superior sectors were significantly decreased in the abnormal group when compared with controls (GEE, P = 0.016, P = 0.001, P = 0.028, P = 0.010, P = 0.012, P = 0.015, P = 0.010, respectively). The cube average macular thickness (CAMT) in the abnormal group was significantly thinner than controls (GEE, P = 0.027).

conclusionsGCIPL measurements using Cirrus-HD OCT detected retinal ganglion cell layer loss following ethambutol treatment, before visual dysfunction occurred.

Indexed as

Optic Nerve DiseasesRetinal Ganglion CellsEthambutolHumansNerve FibersRetinaTomography, Optical CoherenceEthambutolCirrus-HD optical coherence tomographyEthambutolGanglion cell inner plexiform layerRetinal nerve fibre layerToxic optic neuropathy

Identifiers

PMID33691649
PMCPMC7945056
OpenAlexW3135226237

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.