ArticleBMC nephrology2021
Association between physical performance and incidence of end-stage renal disease in older adults: a national wide cohort study.
Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Elevated triglyceride-glucose index is associated with increased risk of chronic kidney disease and end-stage renal disease in type 1 diabetes: Nationwide cohort study.Diabetes, obesity & metabolism · 2026Article
- Shared decision making and decision aids in the management of kidney disease and renal replacement treatment options.Current opinion in nephrology and hypertension · 2026Review
- Effect of exercise intervention on elderly patients with sarcopenia: a meta-analysis.American journal of translational research · 2026Review
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- Article
- Increased Risk of End-Stage Kidney Disease After Traumatic Amputation: Nationwide Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Association of kidney function with physical performance: the Maastricht study.Journal of nephrology · 2024Article
- Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up.Scientific reports · 2023Article
- Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease.GeroScience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical frailty has previously been associated with adverse clinical outcomes in patients with end-stage renal disease (ESRD). This study aimed to determine whether impaired physical performance at baseline is associated with the incidence of ESRD, using a nationwide database.
methodsThe timed up-and-go (TUG) test was used to assess physical frailty in 1,552,781 66-year-old individuals, using health examination database records from the Korean National Health Insurance Service. As a primary endpoint, incident ESRD was defined operationally using healthcare claims data from the Korean Health Insurance Review and Assessment Service.
resultsOur results showed that baseline kidney function was significantly worse in individuals with TUG results of > 10 s compared to individuals with an intact TUG performance (≤10 s). Kaplan-Meier analysis showed a stepwise dose-response relationship between baseline physical performance and the incidence rate of ESRD (log-rank test P-value of < 0.001). An increasing ESRD incidence rate trend with poor physical performance remained significant after adjusting for characteristics such as baseline glomerular filtration rate and proteinuria.
conclusionPoor baseline physical performance was associated with an increased risk of ESRD, suggesting possible interactions between systemic frailty and vascular aging processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.