ArticleBMC infectious diseases2021
Chronic maternal hepatitis B virus infection and pregnancy outcome- a single center study in Kunming, China.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- [Correlation between hepatitis B virus infection and adverse pregnancy outcomes-a systematic review and meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Pooled it
- The prevalence of hepatitis B in Chinese general population from 2018 to 2022: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- The effect of hepatitis B virus on the risk of pregnancy outcomes: a systematic review and meta-analysis of cohort studies.Virology journal · 2023Pooled it
- Hepatitis B Infection Among Pregnant Women in China: A Systematic Review and Meta-Analysis.Frontiers in public health · 2022Pooled it
- Retrospective analysis of adverse pregnancy outcomes associated with hepatitis B virus infection.BMC pregnancy and childbirth · 2025Article
- Article
- Navigating converging pathways of co-infection: an integrated epidemiological insight into hepatitis B and malaria among pregnant women in the middle belt of Ghana.BMC infectious diseases · 2025Article
- The impact of maternal HBeAg carries status and elevated ALT values on adverse outcomes: a population-based cohort study in 198,049 pregnancies.BMC pregnancy and childbirth · 2025Article
- Effect of Hepatitis B virus infection during pregnancy on the risk of postpartum hemorrhage: a systematic review and meta-analysis.Frontiers in global women's health · 2025Review
- Hepatitis B virus infection during pregnancy and the risk of postpartum hemorrhage: a protocol for systematic review and meta-analysis.International journal of surgery protocols · 2024Article
- Association of maternal SARS-CoV-2 infection at the time of admission for delivery with labor process and outcomes of vaginal birth: A cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Factors associated with adverse pregnancy outcomes of maternal syphilis in Henan, China, 2016-2022.Epidemiology and infection · 2023Article
- Economic analysis of a new four-panel rapid screening test in antenatal care in Kenya, Rwanda, and Uganda.BMC health services research · 2023Article
- Effects of HBsAg carriers on pregnancy complications in pregnant women: a retrospective cohort study.Frontiers in medicine · 2023Article
- Maternal hepatitis B surface antigen Carrier Status and Pregnancy Outcome: A Retrospective Cohort Study.Epidemiology and infection · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChinese population has a high prevalence of chronic hepatitis B virus (HBV) infection, the impact of which on pregnancy outcome remains controversial. A single-center retrospective cohort study was performed in Kunming, a multi-ethnic city in south-western China to examine this issue.
methodsThe singleton pregnancies delivering at ≥28 weeks gestation under our care in 2005-2017 constituted the study cohort. Maternal characteristics and pregnancy outcome were compared between mothers with and without seropositivity for hepatitis B surface antigen (HBsAg) determined at routine antenatal screening.
resultsAmong the 49,479 gravidae in the cohort, the 1624 (3.3%) HBsAg seropositive gravidae had a lower incidence of nulliparity (RR 0.963, 95% CI 0.935-0.992) and having received tertiary education (RR 0.829, 95% CI 0.784-0.827). There was no significant difference in the medical history, pregnancy complications, or labor or perinatal outcome, except that HBV carriers had significantly lower incidence of labor induction (RR 0.827, 95% CI 0.714-0.958) and of small-for-gestational age (SGA) infants (RR 0.854, 95% CI 0.734-0.994). On regression analysis, maternal HBV carriage was independently associated with spontaneous labor (aRR 1.231, 95% CI 1.044-1.451) and reduced SGA infants (aRR 0.842, 95% CI 0.712-0.997).
conclusionsOur 3.3% prevalence of maternal HBV infection was around the lower range determined in the Chinese population. The association with spontaneous labor and reduced SGA infants could have helped to promote the perpetuation of the infection through enhanced survival of the offspring infected at birth, thus explaining the high prevalence in the Chinese population.
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