Evidence map›Paper›PMID 33691599›Full record

ArticleGut microbes

The gut microbiota during the progression of atherosclerosis in the perimenopausal period shows specific compositional changes and significant correlations with circulating lipid metabolites.

Qinghai Meng, Menghua Ma, Weiwei Zhang, Yunhui Bi, Peng Cheng, Xichao Yu, Yu Fu, Ying Chao, Tingting Ji, Jun Li and 5 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
  2. Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Review
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  18. Review
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  20. Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Qinghai MengSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Menghua MaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Weiwei ZhangSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yunhui BiSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Peng ChengSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Xichao YuSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yu FuSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Ying ChaoSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Tingting JiSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Jun LiSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Qi ChenSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Qichun ZhangSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yu LiJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Jinjun ShanFirst School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0000-0001-8079-7950
Huimin BianSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is exacerbated in the perimenopausal period, which significantly increases the incidence rate of cardiovascular disease. The disruption of the gut microbiota has been associated with AS or menopause, but the specific changes of AS-associated gut microbiota in the perimenopausal period remain largely unknown. As lipid abnormalities are mainly responsible for AS, the relationship between lipid metabolism abnormalities and gut microbiota disruptions during menopause is rarely reported hitherto. In the present study, ApoE

Indexed as

Lipid MetabolismPerimenopauseAnimalsAtherosclerosisBacteriaDiet, High-FatDisease ProgressionEstradiolEstrogen Replacement TherapyFecal Microbiota TransplantationFecesFemaleGastrointestinal MicrobiomeLipidsMetabolomicsMiceEstradiolLipidsApoE −/- miceAtherosclerosisgut microbiotalipid metabolomicsmenopause

Identifiers

PMID33691599
PMCPMC7954427
OpenAlexW3135025095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.