Evidence map›Paper›PMID 33691522›Full record

ArticleLaboratory animals2022

Genome editing of avian species: implications for animal use and welfare.

Sudeepta K Panda, Mike J McGrew

Open access · hybridAbstract read
In one paragraph

Article in Laboratory animals, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Cold Spring Harbor protocols · 2026
    Article
  4. Article
  5. Manipulating primordial germ cells from chicken and other bird species.The Journal of reproduction and development · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022
    Review
  13. Avian Primordial Germ Cells Are Bipotent for Male or Female Gametogenesis.Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sudeepta K PandaThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.ORCID https://orcid.org/0000-0001-7903-9255
Mike J McGrewThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.
Roslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/20320000National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/V001124/1
6 · The paper itself

Abstract

Avian species are used as model systems in research and have contributed to ground-breaking concepts in developmental biology, immunology, genetics, virology, cancer and cell biology. The chicken in particular is an important research model and an agricultural animal as a major contributor to animal protein resources for the global population. The development of genome editing methods, including CRISPR/Cas9, to mediate germline engineering of the avian genome will have important applications in biomedical, agricultural and biotechnological activities. Notably, these precise genome editing tools have the potential to enhance avian health and productivity by identifying and validating beneficial genetic variants in bird populations. Here, we present a concise description of the existing methods and current applications of the genome editing tools in bird species, focused on chickens, with attention on animal use and welfare issues for each of the techniques presented.

Indexed as

CRISPR-Cas SystemsGene EditingAnimalsChickensGenomeGerm CellschickenCRISPR/Cas9genome editingPoultrypoultry welfareprimordial germ cells

Identifiers

PMID33691522
PMCPMC8918865
OpenAlexW3135820663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.