ArticleArteriosclerosis, thrombosis, and vascular biology2021
Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Outside-In Signaling as a Detonator-like Stimulus of Integrin Activation by Promoting Both Affinity and Avidity.Biomolecules · 2026Review
- Comparing biomechanical platelet activation in the carotid artery by computational and experimental modeling.Blood vessels, thrombosis & hemostasis · 2026Article
- Programming the beating heart with polymer catalysis: a therapeutic microenvironment revolution.Journal of nanobiotechnology · 2026Review
- [Advances in research on the mechanisms of reactive oxygen species in platelet activation and thrombosis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Review
- Redox Regulation of Megakaryocyte Differentiation and Platelet Biogenesis.Antioxidants (Basel, Switzerland) · 2026Review
- Aβ₁₋₄₀ Enhances Platelet Sensitivity to Thrombin via NADPH Oxidase-ROS Signaling and Integrin αBiomolecules & therapeutics · 2026Article
- NADPH oxidase 2 inhibitor GSK2795039 exerts antiplatelet and antithrombotic activity.Scientific reports · 2025Article
- The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species.Cells · 2025Review
- Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Reactive Oxygen Species Scavenger N-Acetyl-L-Cysteine Reduces Storage-Dependent Decline in IntegrinOxidative medicine and cellular longevity · 2025Article
- Editorial: Biomechanics in blood cell functions and diseases.Frontiers in bioengineering and biotechnology · 2024Article
- Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis.Science signaling · 2023Article
- Integrin βNature communications · 2023Article
- Estrogen receptor beta activity contributes to both tumor necrosis factor alpha expression in the hypothalamic paraventricular nucleus and the resistance to hypertension following angiotensin II in female mice.Neurochemistry international · 2022Article
- Signaling mechanisms of the platelet glycoprotein Ib-IX complex.Platelets · 2022Review
- Saccharides fromExperimental and therapeutic medicine · 2022Article
- Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis.Frontiers in cell and developmental biology · 2022Review
- Autophagy Ameliorates Reactive Oxygen Species-Induced Platelet Storage Lesions.Oxidative medicine and cellular longevity · 2022Article
- AβAntioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Zheng Xu *Department of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Ying Liang *Department of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
M Keegan Delaney *Department of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Yaping ZhangDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Kyungho KimDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Jing LiDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Yanyan BaiDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Jaehyung ChoDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Masuko Ushio-FukaiDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Ni ChengDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
Xiaoping DuDepartment of Pharmacology, University of Illinois at Chicago (Z.X., Y.L., M.K.D., Y.Z., K.K., J.L., Y.B., J.C., M.U.-F., N.C., X.D.).
University of Illinois Chicago · USAugusta University · US
Funding
Mechanisms of integrin signaling and a new anti-platelet/anti-inflammatory approachR35HL150797 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Xiaoping Du · 2020 to 2026
$6.8MSignaling mechanisms of platelet GPIb-IXR01HL062350 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DU, XIAOPING · 2000 to 2017
$6.0MOutside-in signaling mechanisms of platelet integrin alpha-llb-beta3R01HL080264 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DU, XIAOPING · 2007 to 2019
$4.6MThiol isomerases in neutrophil recruitment and thromboinflammatory diseaseR01HL130028 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2016 to 2024
$3.6MNew Strategies for Treating Septic Vasculopathy Inflammation and ThrombosisR01HL125356 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONINI, MARCELO G., DU, XIAOPING · 2014 to 2018
$3.4MRedox Regulation of Cu Importer CTR1 in AngiogenesisR01HL147550 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2020 to 2023
$3.3MMitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and AngiogenesisR01HL160014 · NHLBI · AUGUSTA UNIVERSITY · PI USHIO-FUKAI, MASUKO · 2021 to 2024
$2.0MThiol isomerases and ERO1α in sickle cell vaso-occlusionR01HL148280 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2019 to 2022
$1.9MEro1α in platelet activity and thrombosisR01HL146559 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2020 to 2023
$1.7MRole of intravascular ERO1@ in acute lung injuryR01HL153047 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2020 to 2023
$1.6MProtein Disulfide Isomerase as Novel Redox Sensor in VEGF SignalingR01HL135584 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2017 to 2020
$1.5MIdentification of an inhibitor of PDI-GPIbalpha signaling as a novel antithromboinflammatory agentR33HL154107 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2020 to 2021
$1.1MNHLBI NIH HHS R01 HL062350NHLBI NIH HHS R01 HL080264NHLBI NIH HHS R01 HL125356NHLBI NIH HHS R01 HL130028NHLBI NIH HHS R01 HL135584NHLBI NIH HHS R01 HL146559NHLBI NIH HHS R01 HL147550NHLBI NIH HHS R01 HL148280NHLBI NIH HHS R01 HL153047NHLBI NIH HHS R01 HL160014NHLBI NIH HHS R33 HL154107NHLBI NIH HHS R35 HL150797
Abstract
[Figure: see text].
Indexed as
Mechanotransduction, CellularPlatelet ActivationAnimalsBlood PlateletsEnzyme ActivationFemaleGTP-Binding Protein alpha Subunits, G12-G13Hydrogen PeroxideIntegrin beta3MaleMiceMice, Inbred C57BLMice, KnockoutNADPH Oxidase 2NADPH OxidasesPhosphatidylinositol 3-KinaseCybb protein, mouseGTP-Binding Protein alpha Subunits, G12-G13Hydrogen PeroxideIntegrin beta3NADPH Oxidase 2NADPH Oxidasesneutrophil cytosolic factor 1Phosphatidylinositol 3-KinasePlatelet Factor 4Platelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-aktSyk KinaseSyk protein, mouseglycoproteinintegrinplatelet activationreactive oxygen speciesthrombosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.