ArticleArteriosclerosis, thrombosis, and vascular biology2021
Smooth Muscle Cell-Specific PKM2 (Pyruvate Kinase Muscle 2) Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia.
Open access · bronzeAbstract read
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Energetic Decoding of VSMC Plasticity: Metabolic Reprogramming and Phenotypic Switching.Cardiovascular drugs and therapy · 2026Review
- PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2.Nature communications · 2026Article
- Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.Science advances · 2026Article
- Metabolic Pathways Linking Atherosclerotic Cardiovascular Disease With Metabolic Dysfunction-Associated Steatotic Liver Disease.Current atherosclerosis reports · 2026Review
- Decoding the antihypertensive mechanism of cannabidiol through integrative bioinformatics and machine learning.Journal of cannabis research · 2026Article
- Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.International journal of molecular sciences · 2026Article
- Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation.Circulation · 2026Article
- RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch.Military Medical Research · 2026Article
- Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis.Cell death discovery · 2025Review
- Reprogrammed glucose metabolism in vascular smooth muscle cells and its implications for vascular diseases.Pharmacological research · 2025Review
- Vascular Smooth Muscle Cell Metabolic Reprogramming in Arteriovenous Fistula Failure.Biomedicines · 2025Review
- Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics.Cardiovascular research · 2025Article
- Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Role and Research Progress of Glycolytic Metabolic Reprogramming in Smooth Muscle Cells in Atherosclerosis.International journal of general medicine · 2025Review
- Mechanisms of metabolic reprogramming in abdominal aortic aneurysm.Frontiers in cell and developmental biology · 2025Review
- From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD.Frontiers in immunology · 2025Review
- Identification of Disease-Relevant, Sex-Based Proteomic Differences in iPSC-Derived Vascular Smooth Muscle Cells.International journal of molecular sciences · 2024Article
- Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo.Cardiovascular research · 2024Article
- Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis.Current atherosclerosis reports · 2024Review
- Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities.Nature metabolism · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Manish JainDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City (M.J., N.D., P.D., M.K.N., S.R.L., A.K.C.).
Nirav DhaneshaDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City (M.J., N.D., P.D., M.K.N., S.R.L., A.K.C.).
Prakash DoddapattarDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City (M.J., N.D., P.D., M.K.N., S.R.L., A.K.C.).
Manasa K NayakDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City (M.J., N.D., P.D., M.K.N., S.R.L., A.K.C.).
Liang GuoCVPath Institute, Inc, Gaithersburg, MD (L.G., A.C., A.V.F.).
Anne CornelissenCVPath Institute, Inc, Gaithersburg, MD (L.G., A.C., A.V.F.).
Steven R LentzDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City (M.J., N.D., P.D., M.K.N., S.R.L., A.K.C.).
Aloke V FinnCVPath Institute, Inc, Gaithersburg, MD (L.G., A.C., A.V.F.).
Anil K ChauhanDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City (M.J., N.D., P.D., M.K.N., S.R.L., A.K.C.).
University of Iowa · USCVPath Institute · US
Funding
Targeting Pyruvate Kinase M2: A novel strategy to combat thrombo-inflammationR35HL139926 · NHLBI · UNIVERSITY OF IOWA · PI CHAUHAN, ANIL KUMAR · 2018 to 2024
$5.3MThe University of Iowa's Regional Stroke Research NetworkU24NS107247 · NINDS · UNIVERSITY OF IOWA · PI ENRIQUE Carlos LEIRA · 2018 to 2026
$2.8MNovel therpeautic interventions to treat ischemic strokeR01NS109910 · NINDS · UNIVERSITY OF IOWA · PI CHAUHAN, ANIL KUMAR · 2019 to 2023
$1.8MThe University of Iowa Stroke Preclinical Assessment Center for Neuroprotection in strokeU01NS113388 · NINDS · UNIVERSITY OF IOWA · PI CHAUHAN, ANIL KUMAR, LEIRA, ENRIQUE CARLOS · 2019 to 2021
$1.1MNHLBI NIH HHS R35 HL139926NINDS NIH HHS R01 NS109910NINDS NIH HHS U01 NS113388NINDS NIH HHS U24 NS107247
Abstract
[Figure: see text].
Indexed as
Cell MovementCell ProliferationNeointimaAgedAnimalsCarotid Artery InjuriesCarrier ProteinsCells, CulturedDisease Models, AnimalEnzyme ActivationFemaleGlycolysisHumansHyperplasiaMaleMembrane ProteinsCarrier ProteinsMembrane ProteinsPkm protein, mousePyruvate KinaseThyroid Hormone-Binding ProteinsThyroid Hormonesglycolysishyperplasianeointimaphenotypepyruvate kinase muscle 2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.