ArticleCortex; a journal devoted to the study of the nervous system and behavior2021
Hippocampal functional connectivity development during the first two years indexes 4-year working memory performance.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Effect of high-intensity interval training on hippocampal metabolism in older adolescents.Psychophysiology · 2022Trial
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Convergent and divergent brain-cognition development in early adolescence.Nature communications · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- From rest to meaning: default mode network neuroscience as a design constraint for early childhood education.Frontiers in psychology · 2026Review
- A hierarchical model of early brain functional network development.Trends in cognitive sciences · 2025Review
- Sex differences in brain-behavior relationships in the first 2 years of life.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- White matter microstructure and functional connectivity in the brains of infants with Turner syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Functional structure of local connections and differentiation of cerebral cortex areas in the neonate.NeuroImage · 2024Article
- Socioeconomic status moderates associations between hippocampal development and cognition in preterms.Annals of clinical and translational neurology · 2024Article
- Daytime sleep duration during infancy as an indicator for cognitive development at school age: a prospective cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Longitudinal developmental trajectories of functional connectivity reveal regional distribution of distinct age effects in infancy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Alterations of large-scale functional network connectivity in patients with infantile esotropia before and after surgery.Brain and behavior · 2023Article
- Hippocampal volumes and cognitive performance in children born extremely preterm with and without low-grade intraventricular haemorrhage.Brain structure & function · 2023Article
- Cognitive decline and hippocampal functional connectivity within older Black adults.Human brain mapping · 2022Article
- Abnormal developmental trends of functional connectivity in young children with infantile esotropia.Frontiers in neuroscience · 2022Article
- Maternal vitamin BBMJ open · 2021Article
- Maternal trait anxiety symptoms, frontolimbic resting-state functional connectivity, and cognitive development in infancy.Developmental psychobiology · 2021Article
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7 authors.
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Abstract
The hippocampus is a key limbic region involved in higher-order cognitive processes including learning and memory. Although both typical and atypical functional connectivity patterns of the hippocampus have been well-studied in adults, the developmental trajectory of hippocampal connectivity during infancy and how it relates to later working memory performance remains to be elucidated. Here we used resting state fMRI (rsfMRI) during natural sleep to examine the longitudinal development of hippocampal functional connectivity using a large cohort (N = 202) of infants at 3 weeks (neonate), 1 year, and 2 years of age. Next, we used multivariate modeling to investigate the relationship between both cross-sectional and longitudinal growth in hippocampal connectivity and 4-year working memory outcome. Results showed robust local functional connectivity of the hippocampus in neonates with nearby limbic and subcortical regions, with dramatic maturation and increasing connectivity with key default mode network (DMN) regions resulting in adult-like topology of the hippocampal functional connectivity by the end of the first year. This pattern was stabilized and further consolidated by 2 years of age. Importantly, cross-sectional and longitudinal measures of hippocampal connectivity in the first year predicted subsequent behavioral measures of working memory at 4 years of age. Taken together, our findings provide insight into the development of hippocampal functional circuits underlying working memory during this early critical period.
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