ReviewCell2021
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation.
Review in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed.
- Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice.Nature neuroscience · 2026Article
- Social Physiology: Human homeostasis is more efficient in social proximity.Science advances · 2026Article
- Cross-Species Social Experience Suppresses Aggression in Drosophila.Neuroscience bulletin · 2026Article
- Social isolation disrupts prefrontal excitatory-inhibitory balance to impair social novelty memory in adult male mice.Translational psychiatry · 2026Article
- Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Nature communications · 2026Article
- Experiences of hemodialysis in patients with end-stage renal disease: a patient journey map based on a qualitative study.BMC nephrology · 2026Article
- Factors Modulating the Effects of Juvenile Social Isolation on Adult Social Behavior in Rodents.Developmental psychobiology · 2026Review
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- An idiographic network approach to modeling daily loneliness and paranoia in psychosis: implications for personalized interventions.Frontiers in psychiatry · 2026Article
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- An automated two-choice social operant task for probing moment-to-moment changes in social satiety.iScience · 2025Article
- The temporal relationships between social motivation and social interactions in people with serious mental illness and recent homelessness.Journal of mental health (Abingdon, England) · 2025Article
- Age-specific regulation of sociability by hypothalamic Agrp neurons.Current biology : CB · 2025Article
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities.Molecular brain · 2025Article
- Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state.eLife · 2025Article
- Prosocial Helping Behavior: Conceptual Issues and Neural Mechanisms.Biological psychiatry · 2025Review
- Opioid Regulation of Social Homeostasis: Connecting Loneliness to Addiction.Biological psychiatry · 2025Review
- Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats.Psychopharmacology · 2025Article
- Oxytocin signaling in the ventral tegmental area mediates social isolation-induced craving for social interaction.Journal of biomedical science · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Social homeostasis is the ability of individuals to detect the quantity and quality of social contact, compare it to an established set-point in a command center, and adjust the effort expended to seek the optimal social contact expressed via an effector system. Social contact becomes a positive or negative valence stimulus when it is deficient or in excess, respectively. Chronic deficits lead to set-point adaptations such that reintroduction to the previous optimum is experienced as a surplus. Here, we build upon previous models for social homeostasis to include adaptations to lasting changes in environmental conditions, such as with chronic isolation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.