ArticleImmunity2021
Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
15.1field-weighted citation impact, top 1% of its field
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Who cites it
93 citing papers in PubMed, 140 citations in OpenAlex.
- Trial
- Review
- Enteric ChAT-Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Intestinal muscularis in health and disease.Communications biology · 2026Review
- Dendritic Cells as Immunometabolic Regulatory Nodes in Diabetes: Molecular Mechanisms and Therapeutic Reprogramming.International journal of molecular sciences · 2026Review
- Interleukin-6 Signaling Mediates Mitochondrial Fragmentation and Mitophagy Impairment to Induce Macrophages Ferroptosis in Atherosclerosis.Inflammation · 2026Article
- Enteric nervous system in exercise physiology: a microbiota-neural interface.npj metabolic health and disease · 2026Review
- Short-Chain Fatty Acids Elicit Differential Expression of Growth Factors and Pro-Inflammatory Cytokines in Immortalized Rat Enteric Glial Cells.Nutrients · 2026Article
- Peripheral Blood Regulatory T Cells and IL-6 are Associated with Cognitive Impairment After Acute Ischemic Stroke.Neuropsychiatric disease and treatment · 2026Article
- Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Article
- Interleukin-6 in complications of prematurity: from biomarker to targeted therapy.Frontiers in pediatrics · 2026Review
- The role of gut microbiota in neuropathic pain: insights into immune mechanisms.The journal of headache and pain · 2025Review
- Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease.Gut microbes · 2025Article
- T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota.Gut microbes · 2025Article
- Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive molecules.Ageing research reviews · 2025Review
- Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification.Gut microbes · 2025Review
- Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis.Nature communications · 2025Article
- Immunomodulatory Effects ofCurrent issues in molecular biology · 2025Review
33 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 3 institutions in 2 countries.
Yiqing YanDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Deepshika RamananDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Milena RozenbergDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Kelly McGovernDepartment of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Daniella RastelliDepartment of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Brinda VijaykumarDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Omar YaghiDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Tiphaine VoisinDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Munir MosahebDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Isaac ChiuDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Shalev ItzkovitzDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Meenakshi RaoDepartment of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston MA 02115, USA. Electronic address: cbdm@hms.harvard.edu.
Harvard University · USBoston Children's Hospital · USWeizmann Institute of Science · IL
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MPain and Neuro-immune Signaling in S. pyogenes pathogenesisR01AI130019 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG, WESSELS, MICHAEL R · 2017 to 2021
$3.2MSensory Neuron-Bacteria Interactions in Modulating Pain and the Host MicrobiotaDP2AT009499 · NCCIH · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2016 to 2019
$2.7MNociceptor neuron regulation of gastrointestinal barrier protection and host defenseR01DK127257 · NIDDK · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2021 to 2024
$2.2MT regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1MEnteric Glia, Sexual Dimorphism and GI MotilityK08DK110532 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAO, MEENAKSHI · 2016 to 2021
$862kNCCIH NIH HHS DP2 AT009499NIAID NIH HHS N01 AI030019NIAID NIH HHS R01 AI125603NIAID NIH HHS R01 AI130019NIDDK NIH HHS K08 DK110532NIDDK NIH HHS R01 DK127257NIGMS NIH HHS T32 GM007753
Abstract
The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3
Indexed as
AnimalsCell DifferentiationCell ProliferationCells, CulturedCoculture TechniquesEnteric Nervous SystemGastrointestinal MicrobiomeInterleukin-6IntestinesMiceMice, Inbred C57BLMice, KnockoutNeuronsNeurotransmitter AgentsNuclear Receptor Subfamily 1, Group F, Member 3PhenotypeInterleukin-6Neurotransmitter AgentsNuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mousegut-brain axisneuro-immune interactionsregulatory T cellsTreg-neuron interactions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.