Evidence map›Paper›PMID 33691090›Full record

ArticleCell metabolism2021

CD36-mediated ferroptosis dampens intratumoral CD8

Xingzhe Ma, Liuling Xiao, Lintao Liu, Lingqun Ye, Pan Su, Enguang Bi, Qiang Wang, Maojie Yang, Jianfei Qian, Qing Yi

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 669 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
669citing papers in PubMed, 2 pooled it
89.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

669 citing papers in PubMed, 2 syntheses or guidelines pooled it, 888 citations in OpenAlex.

  1. Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026
    Pooled it
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  16. Ferroptosis as a target mechanism in heart and kidney disease.The Journal of clinical investigation · 2026
    Review
  17. Article
  18. Article
  19. The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy.International journal of molecular sciences · 2026
    Review
  20. Article

609 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xingzhe MaCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Liuling XiaoCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Lintao LiuCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Lingqun YeCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Pan SuCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Enguang BiCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Qiang WangCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Maojie YangCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Jianfei QianCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA.
Qing YiCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist, Houston, TX 77030, USA. Electronic address: qyi@houstonmethodist.org.
Houston Methodist · US

Funding

Role of tumor microenvironment-derived cholesterol in CD8+ T-cell exhaustionR01CA239255 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2019 to 2023
$2.1M
Role of MIF in myeloma bone homing and drug responseR01CA211073 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2017 to 2021
$1.8M
A novel T-cell subset able to kill relapsed cancersR01CA200539 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2016 to 2020
$1.8M
Targeting macrophages to sensitize myeloma to immune checkpoint blockadeR01CA214811 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA200539NCI NIH HHS R01 CA211073NCI NIH HHS R01 CA214811NCI NIH HHS R01 CA239255
6 · The paper itself

Abstract

Understanding the mechanisms underlying how T cells become dysfunctional in a tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8

Indexed as

FerroptosisAnimalsAntibodies, Monoclonal, HumanizedCD36 AntigensCD8-Positive T-LymphocytesCell Line, TumorCytokinesFatty AcidsHumansImmunotherapyLipid PeroxidationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutMultiple MyelomaAntibodies, Monoclonal, HumanizedCD36 AntigensCytokinesFatty AcidsReactive Oxygen SpeciesspartalizumabCD36CD8(+) T cellsferroptosislipid peroxidation

Identifiers

PMID33691090
PMCPMC8102368
OpenAlexW3134959125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.