ArticleOral diseases2022
Shared microbiological and immunological patterns in periodontitis and IBD: A scoping review.
Article in Oral diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis.BMC gastroenterology · 2025Pooled it
- Meta-analysis on the association between the frequency of tooth brushing and hypertension risk.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Metagenomics in the Interplay Among Oral and Gut Dysbiosis.Metabolites · 2026Review
- Revisiting the Oral-Gut Axis: Microbial Symbiosis, Dysbiosis, and Bidirectional Links Between Periodontitis and Inflammatory Bowel Disease.Microorganisms · 2026Review
- [The Impact of Oral Microecology on the Development of Inflammatory Bowel Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- The bidirectional effects and mechanisms of the oral and gut microbiomes: a narrative review.Frontiers in immunology · 2026Review
- Association between a novel Dietary Index for Gut Microbiota and periodontitis: a cross-sectional study.Frontiers in nutrition · 2026Article
- Impact of anti-TNF and anti-IL-12/IL-23 antibody therapy on periodontal inflammation and gingival crevicular fluid IL-6 in patients with inflammatory bowel diseases.Frontiers in immunology · 2026Article
- Lactylation-related gene signatures define immune heterogeneity and provide diagnostic biomarkers for periodontitis.Scientific reports · 2025Article
- Prevalence and Severity of Periodontitis in Patients with Ulcerative Colitis: A Case-Control Study.International journal of environmental research and public health · 2025Article
- Periodontitis-associated Fusobacterium nucleatum promotes ulcerative colitis by ferroptosis-mediated gut barrier disruption.NPJ biofilms and microbiomes · 2025Article
- Influence of CTG repeats from the human DM1 locus on murine gut microbiota.Computational and structural biotechnology journal · 2025Article
- The Oral Microbiota and Its Implications for Inflammatory Bowel Disease: A Literature Review.International journal of general medicine · 2025Review
- The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis.Frontiers in genetics · 2025Article
- Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD.Nutrients · 2024Review
- Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.Journal of Crohn's & colitis · 2024Review
- Immune-mediated inflammatory diseases and periodontal disease: a bidirectional two-sample mendelian randomization study.BMC immunology · 2024Article
- Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis.Nature communications · 2024Article
- The involvement of oral bacteria in inflammatory bowel disease.Gastroenterology report · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo extract the microbiological and immunological evidence underpinning the association between periodontitis and inflammatory bowel disease (IBD).
methodsRelevant articles were sorted through a systematic search on PubMed, Embase, Scopus and Web of Science up to October 2020. Available evidence was grouped in three different clusters: (a) studies that examined oral microbial alterations in IBD patients; (b) studies that investigated intestinal dysbiosis in patients with periodontitis; and (c) evidence for a shared immunological pattern between the two conditions.
resultsA total of 15 studies involving 1,171 patients were included. Oral microbiome, either subgingival or salivary, was consistently altered in patients with IBD compared to healthy subjects (a) Additionally, gut dysbiotic microbiota of IBD patients was colonized by pathobionts from oral origin, either via haematogenous or enteric route. Suffering from periodontitis is associated with lower alpha diversity in the gut microbiome (b) Lastly, both IBD and periodontitis are characterized by similar expression patterns of inflammatory cytokines at the gingival and gut levels that are exacerbated when both diseases are present (c).
conclusionsPeriodontitis and IBD share common dysbiotic and immunological traits. Well-designed preclinical models and longitudinal cohort studies are required to better explore the causal pathways between the two conditions (PROSPERO CRD42020194379).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.