ArticleCerebral cortex (New York, N.Y. : 1991)2021
Multimodal Image Analysis of Apparent Brain Age Identifies Physical Fitness as Predictor of Brain Maintenance.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Trial
- Your brain doesn't look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-old.GeroScience · 2026Article
- Article
- Article
- Preserved brain youthfulness: longitudinal evidence of slower brain aging in superagers.GeroScience · 2025Article
- No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts.Scientific reports · 2025Article
- Assessing the Utility of Predicted Brain Age for Explaining Variability in Language Abilities in Healthy Older Adults.Neurobiology of language (Cambridge, Mass.) · 2025Article
- A multimodal ensemble stacking model improves brain age prediction and reveals associations with schizophrenia symptoms.Frontiers in psychiatry · 2025Article
- The analysis of aerobics intelligent fitness system for neurorobotics based on big data and machine learning.Heliyon · 2024Article
- Prediction of cognitive performance differences in older age from multimodal neuroimaging data.GeroScience · 2024Article
- Diffusion deep learning for brain age prediction and longitudinal tracking in children through adulthood.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Extensive T1-weighted MRI Preprocessing Improves Generalizability of Deep Brain Age Prediction Models.bioRxiv : the preprint server for biology · 2023Article
- Effects of acute physical activity on brain metabolites as measured by magnetic resonance spectroscopy (Heliyon · 2023Article
- A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility.Patterns (New York, N.Y.) · 2023Review
- White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging.Translational psychiatry · 2023Article
- Observational
- Brain age prediction using the graph neural network based on resting-state functional MRI in Alzheimer's disease.Frontiers in neuroscience · 2023Article
- Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.Scientific reports · 2022Article
- Neuroimaging-Based Brain Age Estimation: A Promising Personalized Biomarker in Neuropsychiatry.Journal of personalized medicine · 2022Review
- Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease.NeuroImage · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintaining a youthful brain structure and function throughout life may be the single most important determinant of successful cognitive aging. In this study, we addressed heterogeneity in brain aging by making image-based brain age predictions and relating the brain age prediction gap (BAPG) to cognitive change in aging. Structural, functional, and diffusion MRI scans from 351 participants were used to train and evaluate 5 single-modal and 4 multimodal prediction models, based on 7 regression methods. The models were compared on mean absolute error and whether they were related to physical fitness and cognitive ability, measured both currently and longitudinally, as well as study attrition and years of education. Multimodal prediction models performed at a similar level as single-modal models, and the choice of regression method did not significantly affect the results. Correlation with the BAPG was found for current physical fitness, current cognitive ability, and study attrition. Correlations were also found for retrospective physical fitness, measured 10 years prior to imaging, and slope for cognitive ability during a period of 15 years. The results suggest that maintaining a high physical fitness throughout life contributes to brain maintenance and preserved cognitive ability.
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