Evidence map›Paper›PMID 33690844›Full record

ArticleBlood2021

Vacuolization of hematopoietic precursors: an enigma with multiple etiologies.

Carmelo Gurnari, Simona Pagliuca, Lisa Durkin, Laila Terkawi, Hassan Awada, Sunisa Kongkiatkamon, Misam Zawit, Eric D Hsi, Hetty E Carraway, Heesun J Rogers and 2 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Blood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Vacuolated Marrow Cytopenias from Copper Deficiency toInternational journal of molecular sciences · 2025
    Pooled it
  3. Pooled it
  4. Myelodysplasia in VEXAS syndrome.Blood advances · 2026
    Review
  5. Article
  6. Article
  7. VEXAS syndrome.Nature reviews. Disease primers · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. VEXAS syndrome.International journal of hematology · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Painful Diplopia as an Initial Presentation of VEXAS Syndrome.Neuro-ophthalmology (Aeolus Press) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carmelo GurnariTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.ORCID 0000-0001-6829-5544
Simona PagliucaTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.
Lisa DurkinDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, OH; and.
Laila TerkawiTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.
Hassan AwadaTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.
Sunisa KongkiatkamonTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.
Misam ZawitTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-2991-4386
Eric D HsiDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, OH; and.
Hetty E CarrawayTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.ORCID 0000-0001-5241-3614
Heesun J RogersDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, OH; and.ORCID 0000-0001-8491-224X
Valeria VisconteTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-2993-1509
Jaroslaw P MaciejewskiTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.

Funding

Therapeutic Implications of Molecular Defects in Bone Marrow FailureR35HL135795 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MACIEJEWSKI, JAROSLAW P. · 2017 to 2023
$5.7M
Novel Spliceosomal Defects in Myelodysplastic SyndromesR01HL132071 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MACIEJEWSKI, JAROSLAW P., PADGETT, RICHARD A · 2016 to 2019
$2.4M
RNA Helicase Mutations in Myelodysplastic Syndrome: New Therapeutic TargetR01HL123904 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI JANKOWSKY, ECKHARD, MACIEJEWSKI, JAROSLAW P. · 2015 to 2018
$2.1M
Investigations of Consequences of U2AF1 Mutations in MDSR01HL118281 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MACIEJEWSKI, JAROSLAW P., PADGETT, RICHARD A · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL118281NHLBI NIH HHS R01 HL123904NHLBI NIH HHS R01 HL132071NHLBI NIH HHS R35 HL135795
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bone Marrow CellsErythroid CellsGenes, X-LinkedMutationMyeloid CellsMyeloid Progenitor CellsMyeloproliferative DisordersVacuolesAdultAgedAged, 80 and overChildFemaleHumansMaleMiddle AgedUBA1 protein, humanUbiquitin-Activating Enzymes

Identifiers

PMID33690844
PMCPMC8462399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.