Trial reportPloS one2021
Challenging drug-resistant TB treatment journey for children, adolescents and their care-givers: A qualitative study.
Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Youth-friendly health services for tuberculosis care: an integrative review and implementation science synthesis.BMC health services research · 2026Pooled it
- Barriers and facilitators to pediatric tuberculosis management in India: a systematic review.BMC infectious diseases · 2025Pooled it
- Caregiver Burden Among Families of Paediatric Patients With Tuberculosis: A Mixed-Methods Study.Journal of advanced nursing · 2026Article
- Depressive Symptoms in Pediatric Tuberculosis: A Retrospective Two-Time-Point Observational Study.Diseases (Basel, Switzerland) · 2026Article
- Factors Associated with Parental Involvement in Efforts to Prevent Drug-Resistant Tuberculosis in Children: A Scoping Review.Infection and drug resistance · 2026Review
- Acceptability of a clofazimine tablet in children with rifampicin-resistant TB in three high-burden countries.IJTLD open · 2025Article
- Clinical best practices for caring for people with expanded resistance to newer TB drugs.IJTLD open · 2025Review
- Understanding the relationship between adolescents with tuberculosis and health services: an indepth qualitative study from Cape Town.BMJ open · 2025Observational
- Efficacy and safety data on pretomanid for drug-resistant TB.IJTLD open · 2025Review
- Article
- Children, caregivers and health workers' perceptions and experiences of the XTEMP-R tool to improve tuberculosis treatment.PLOS global public health · 2025Article
- Experiences of children and their caregivers affected by multidrug-resistant tuberculosis in Cape Town, South Africa.PloS one · 2025Article
- Collaboration for implementation of decentralisation policy of multi drug-resistant tuberculosis services in Zambia.Health research policy and systems · 2024Article
- Manipulation of solid dosage forms for oral administration to paediatric patients for drug-resistant tuberculosis in South Africa: an observation study.BMC pediatrics · 2024Observational
- Why do patients with DR-TB do not complete their treatment? Findings of a qualitative study from Pakistan.BMJ open respiratory research · 2024Article
- Correction: Challenging drug-resistant TB treatment journey for children, adolescents and their care-givers: A qualitative study.PloS one · 2024Article
- South African adolescents' lived experiences of acquired hearing loss following multidrug-resistant tuberculosis treatment.Frontiers in rehabilitation sciences · 2024Article
- Psychosocial experiences of adolescents with tuberculosis in Cape Town.PLOS global public health · 2024Article
- The trial of sending short message service multidrug-resistant tuberculosis patients in Indonesia: the chance to increase knowledge and motivation.Journal of public health in Africa · 2023Article
- Organisation of care for people receiving drug-resistant tuberculosis treatment in South Africa: a mixed methods study.BMJ open · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood multidrug-resistant TB (MDR-TB) still affects around 25000 children every year across the globe. Though the treatment success rates for drug-resistant TB (DR-TB) in children are better than adults, children and adolescents face unique hurdles during DR-TB (MDR-TB, Pre-XDR TB and XDR-TB) treatment. This study aimed to understand the patients, guardians and healthcare providers' perspectives about DR-TB treatment journey of patients and caregivers.
methodsThis is a qualitative study involving in depth-interviews of purposively selected adolescents (n = 6), patients guardians (for children and adolescents, n = 5) and health care providers (n = 8) of Médecins Sans Frontières (MSF) clinic, Mumbai, India. In-depth face to face interviews were conducted in English or Hindi language using interview guides during September-November 2019. The interviews were audio-recorded after consent. Thematic network analysis was used to summarize textual data. ATLAS.ti (version 7) was used for analysis.
resultThe age of adolescent patients ranged from 15-19 years and four were female. Five guardians (of three child and two adolescent patients) and eight healthcare providers (including clinicians- 2, DOT providers-2, counselors-2 and programme managers-2) were interviewed. The overarching theme of the analysis was: Challenging DR-TB treatment journey which consisted of four sub-themes: 1) physical-trauma, 2) emotional-trauma, 3) unavailable social-support and 4) non-adapted healthcare services. Difficulties in compounding of drugs were noted for children while adolescents shared experiences around disruption in social life due to disease and treatment. Most of the patients and caregivers experienced treatment fatigue and burnout during the DR-TB treatment. Participants during interviews gave recommendations to improve care. DISCUSSION: The TB programmes must consider the patient and family as one unit when designing the package of care for paediatric DR-TB. Child and adolescent friendly services (paediatric-formulations, age-specific counselling tools and regular interaction with patients and caregivers) will help minimizing burnout in patients and caregivers.
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