ArticlePloS one2021
Post-intensive care syndrome as a predictor of mortality in patients with critical illness: A cohort study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Prevalence and incidence of post-intensive care syndrome among intensive care unit survivors: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- Cognitive Functioning After Circulatory Shock: A Prospective Observational Study.Acta anaesthesiologica Scandinavica · 2026Observational
- Development and validation of a knowledge, attitude and practice questionnaire of occupational therapy.Scientific reports · 2026Article
- Recovery After Critical Illness: A Meta-Ethnography of Patient, Family and Staff Perspectives.Journal of advanced nursing · 2026Review
- Article
- Article
- Implementation and Challenges of Early-Phase Physiotherapy During Cardiovascular Intensive Care.Circulation reports · 2026Review
- Trajectories of post-discharge cognitive function and associated risk factors in ICU survivors: a secondary analysis.Scientific reports · 2025Article
- Novel Strategies to Promote Intensive Care Unit Recovery via Personalized Exercise, Nutrition, and Anabolic Interventions.Critical care clinics · 2025Review
- Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study.Infection · 2025Observational
- Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies.Annals of intensive care · 2025Review
- Comprehensive assessment and progression of health status during neurorehabilitation in survivors of critical illness: a prospective cohort study.Annals of intensive care · 2024Article
- Incidence of post-intensive care syndrome among patients admitted to post-ICU multidisciplinary consultations: the retrospective observational PICS-MIR study.Scientific reports · 2024Observational
- Post intensive care syndrome: A review of clinical symptoms, evaluation, intervention.Heliyon · 2024Review
- Article
- Beyond survival: understanding post-intensive care syndrome.Acute and critical care · 2024Article
- Latent Trajectories of Activities of Daily Living Disability and Associated Factors Among Adults with Post-Intensive Care Syndrome One Week After ICU Discharge.Journal of multidisciplinary healthcare · 2024Article
- Trajectories of Short-Term Post-Traumatic Stress Disorder Symptoms in Patients with Post-Intensive Care Syndrome: A Longitudinal Observational Study.International journal of general medicine · 2024Article
- Sepsis and COVID-19: outcomes in young adults in intensive care.Revista brasileira de enfermagem · 2023Article
- Post-Intensive Care Syndrome in Non-COVID-19 ICU Survivors during the COVID-19 Pandemic in South Korea: A Multicenter Prospective Cohort Study.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionThe post-intensive care syndrome (PICS) encompasses multiple, diverse conditions, such as physical disability, cognitive impairment, and depression. We sought to evaluate whether conditions within PICS have similar associations with mortality among survivors of critical illness. MATERIALS AND
methodsIn this retrospective cohort study, we identified 248 critically ill patients with intensive care unit stay ≥72 hours, who underwent PICS evaluation. Patients with disability in activities of daily living, cognitive impairment, or depression before hospitalization were excluded. We defined PICS using established measures of physical disability (usual gait speed), cognitive impairment (Mini-Cog test), and depression (Patient Health Questionnaire-2) at hospital discharge. The endpoint was all-cause mortality.
resultsPatients had a median age of 69 years and Acute Physiology and Chronic Health Evaluation (APACHE) II score of 16. One hundred thirty-two patients were classified as having PICS, and 19 patients died. 81/248 (34%) patients had physical disability, 42/248 (19%) had cognitive impairment, and 44/248 (23%) had depression. After adjusting for covariates on multivariable Cox regression analyses, PICS was significantly associated with all-cause mortality (hazard ratio [HR] 3.78, 95% confidence interval [CI] 1.02 - 13.95; P = 0.046). However, the association between PICS and all-cause mortality was related to physical disability and cognitive impairment (P = 0.001 and P = 0.027, respectively), while depression was not (P = 0.623).
conclusionWhile PICS as a syndrome has been useful in gaining attention to the sequelae of critical illness, its relationship with long-term mortality is driven largely by physical disability and cognitive impairment and not depression.
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