Evidence map›Paper›PMID 33689817›Full record

ArticleActa biomaterialia2021

Angiogenic hydrogels for dental pulp revascularization.

Zain Siddiqui, Biplab Sarkar, Ka-Kyung Kim, Nurten Kadincesme, Reshma Paul, Arjun Kumar, Yoshifumi Kobayashi, Abhishek Roy, Marwa Choudhury, Jian Yang and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Tissue Characteristics in Endodontic Regeneration: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
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  14. Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zain SiddiquiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Biplab SarkarDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Ka-Kyung KimDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Nurten KadincesmeDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Reshma PaulDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Arjun KumarDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Yoshifumi KobayashiDepartment of Oral Biology, Department of Endodontics, Rutgers School of Dental Medicine, Newark, NJ, USA.
Abhishek RoyDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Marwa ChoudhuryDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Jian YangDepartment of Biomedical Engineering, Huck Institutes of The Life Sciences, Materials Research Institute, Pennsylvania State University, University Park, PA, USA.
Emi ShimizuDepartment of Oral Biology, Department of Endodontics, Rutgers School of Dental Medicine, Newark, NJ, USA.
Vivek A KumarDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA; Department of Oral Biology, Department of Endodontics, Rutgers School of Dental Medicine, Newark, NJ, USA; Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ, USA; Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, NJ, USA. Electronic address: vak@njit.edu.
New Jersey Institute of Technology · USRutgers, The State University of New Jersey · USPennsylvania State University · US

Funding

Growth factors-induced dentinogenesisR01DE025885 · NIDCR · RBHS-SCHOOL OF DENTAL MEDICINE · PI SHIMIZU, EMI · 2016 to 2021
$2.1M
Citrate Metabonegenic Regulation for the next Generation of Orthopedic Biomaterial DesignR01AR072731 · NIAMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI YANG, JIAN · 2018 to 2022
$1.7M
Peptide hydrogels for management and treatment of neovascular posterior segment diseasesR15EY029504 · NEI · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI KUMAR, VIVEK · 2019 to 2020
$508k
NEI NIH HHS R15 EY029504NIAMS NIH HHS R01 AR072731NIDCR NIH HHS R01 DE025885
6 · The paper itself

Abstract

Angiogenesis is critical for tissue healing and regeneration. Promoting angiogenesis in materials implanted within dental pulp after pulpectomy is a major clinical challenge in endodontics. We demonstrate the ability of acellular self-assembling peptide hydrogels to create extracellular matrix mimetic architectures that guide in vivo development of neovasculature and tissue deposition. The hydrogels possess facile injectability, as well as sequence-level functionalizability. We explore the therapeutic utility of an angiogenic hydrogel to regenerate vascularized pulp-like soft tissue in a large animal (canine) orthotopic model. The regenerated soft tissue recapitulates key features of native pulp, such as blood vessels, neural filaments, and an odontoblast-like layer next to dentinal tubules. Our study establishes angiogenic peptide hydrogels as potent scaffolds for promoting soft tissue regeneration in vivo. STATEMENT OF SIGNIFICANCE: A major challenge to endodontic tissue engineering is the lack of in situ angiogenesis within intracanal implants, especially after complete removal of the dental pulp. The lack of a robust vasculature in implants limit integration of matrices with the host tissue and regeneration of soft tissue. We demonstrate the development of an acellular material that promotes tissue revascularization in vivo without added growth factors, in a preclinical canine model of pulp-like soft-tissue regeneration. Such acellular biomaterials would facilitate pulp revascularization approaches in large animal models, and translation into human clinical trials.

Indexed as

Dental PulpHydrogelsAnimalsBiocompatible MaterialsExtracellular MatrixHumansTissue EngineeringTissue ScaffoldsBiocompatible MaterialsHydrogelsAcellular scaffoldsAngiogenesisPulp revascularizationSelf-assemblyTissue regeneration

Identifiers

PMID33689817
PMCPMC8096688
OpenAlexW3135759519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.