ArticleDevelopmental cell2021
Coupled oscillators coordinate collective germline growth.
Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Gap junctions allow transfer of metabolites between germ cells and somatic cells to promote germ cell growth in the Drosophila ovary.PLoS biology · 2025Article
- ERK synchronizes embryonic cleavages in Drosophila.Developmental cell · 2024Article
- Lineage-based scaling of germline intercellular bridges during oogenesis.Development (Cambridge, England) · 2024Article
- A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design.Cell · 2024Article
- A model of replicating coupled oscillators generates naturally occurring cell networks.Development (Cambridge, England) · 2023Article
- Go with the flow - bulk transport by molecular motors.Journal of cell science · 2023Review
- Fusome topology and inheritance during insect gametogenesis.PLoS computational biology · 2023Article
- Mechanics of stabilized intercellular bridges.Biophysical journal · 2022Article
- Using balloons and rubber bands to learn about inter-cellular bridges.Biophysical journal · 2022Article
- Quantitative models for building and growing fated small cell networks.Interface focus · 2022Review
- Noncanonical function of Capicua as a growth termination signal inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.Cell reports · 2022Article
- Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila.Trends in cell biology · 2022Review
- Collective oscillations of coupled cell cycles.Biophysical journal · 2021Article
- A topological look into the evolution of developmental programs.Biophysical journal · 2021Article
- Size scaling in collective cell growth.Development (Cambridge, England) · 2021Article
- Gatekeeper function for Short stop at the ring canals of the Drosophila ovary.Current biology : CB · 2021Article
- Direct Imaging of Lipid Metabolic Changes inFrontiers in aging · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Developing oocytes need large supplies of macromolecules and organelles. A conserved strategy for accumulating these products is to pool resources of oocyte-associated germline nurse cells. In Drosophila, these cells grow more than 100-fold to boost their biosynthetic capacity. No previously known mechanism explains how nurse cells coordinate growth collectively. Here, we report a cell cycle-regulating mechanism that depends on bidirectional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulator of germline cyst growth. Transcripts encoding the cyclin-dependent kinase inhibitor, Dacapo, are synthesized by the nurse cells and actively localized to the oocyte. Retrograde movement of the oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators that controls the cell cycle of the nurse cells to regulate cyst growth. We propose that bidirectional nurse cell-oocyte communication establishes a growth-sensing feedback mechanism that regulates the quantity of maternal resources loaded into the oocyte.
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