Evidence map›Paper›PMID 33689572›Full record

ArticleSeminars in ophthalmology2021

Serum Biomarkers in Neuro-Ophthalmology: When to Test.

Devon A Cohen, Ryan Gise, Eric D Gaier

Abstract read
In one paragraph

Article in Seminars in ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Devon A CohenDepartment of Ophthalmology, Harvard Medical School, Boston.ORCID https://orcid.org/0000-0002-0160-8435
Ryan GiseDepartment of Ophthalmology, Harvard Medical School, Boston.
Eric D GaierDepartment of Ophthalmology, Harvard Medical School, Boston.

Funding

Exploiting principles of timing-dependent synaptic plasticity to treat amblyopiaK08EY030164 · NEI · BOSTON CHILDREN'S HOSPITAL · PI GAIER, ERIC DEAN · 2019 to 2023
$1.2M
NEI NIH HHS K08 EY030164
6 · The paper itself

Abstract

Discovery and characterization of serologic biomarkers has revolutionized the diagnostic framework of systemic and paraneoplastic autoimmune neuro-ophthalmic diseases. Expanding recognition of the multiple ocular and visual manifestations of these conditions highlights the important role of the referring provider in identifying potential cases. Increasing ease of access to serologic testing also enables these practitioners to initiate the diagnostic work-up in suspected cases. We aimed to provide an update on the current knowledge surrounding and use of relevant autoimmune biomarkers by correlating specific clinical neuro-ophthalmic manifestations with autoantibody biomarkers. The utility of select biomarkers for myasthenia gravis, neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein-IgG-associated disorder, opsoclonus-myoclonus syndrome, anti-collapsin-response mediator protein-5 optic neuropathy, and glial fibrillary acidic protein-IgG-associated disease are discussed with particular focus on the clinical contexts in which to consider testing.

Indexed as

Neuromyelitis OpticaOphthalmologyOptic Nerve DiseasesAutoantibodiesBiomarkersHumansAutoantibodiesBiomarkersAutoantibodiesautoimmune neuro-ophthalmic disordersneuro-ophthalmologyparaneoplastic syndromesserum biomarkers

Identifiers

PMID33689572
PMCPMC10329253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.