Evidence map›Paper›PMID 33689515›Full record

ArticleJournal of neurophysiology2021

Estimating the effects of slicing on the electrophysiological properties of spinal motoneurons under normal and disease conditions.

Mohamed H Mousa, Sherif M Elbasiouny

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mohamed H MousaDepartment of Biomedical, Industrial and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, Ohio.
Sherif M ElbasiounyDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, Ohio.ORCID 0000-0002-6227-3894

Funding

The impact of neuromodulatory state on the excitability changes of motoneurons and the motor pool in ALSR01NS091836 · NINDS · WRIGHT STATE UNIVERSITY · PI Sherif M Elbasiouny · 2015 to 2026
$4.7M
NASEM | National Academy of Sciences (NAS) 2000009148NINDS NIH HHS R01 NS091836
6 · The paper itself

Abstract

Although slice recordings from spinal motoneurons (MNs) are being widely used, the effects of slicing on the measured MN electrical properties under normal and disease conditions have not been assessed. Using high-fidelity cell models of neonatal wild-type (WT) and superoxide dismutase-1 (SOD) cells, we examined the effects of slice thickness, soma position within the slice, and slice orientation to estimate the error induced in measured MN electrical properties from spinal slices. Our results show that most MN electrical properties are not adversely affected by slicing, except for cell time constant, cell capacitance, and Ca

Indexed as

Models, NeurologicalAmyotrophic Lateral SclerosisAnimalsElectrophysiological PhenomenaMiceMotor NeuronsSpinal CordSuperoxide Dismutase-1Superoxide Dismutase-1ALSslice preparationspinal motoneurons

Identifiers

PMID33689515
PMCPMC8282222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.