Evidence map›Paper›PMID 33689481›Full record

ArticleAmerican journal of physiology. Cell physiology2021

A nonolfactory shark adenosine receptor activates CFTR with unique pharmacology and structural features.

Sumeet Bhanot, Gabriele Hemminger, Cole L Martin, Stephen G Aller, John N Forrest

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sumeet BhanotRenal Section, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Gabriele HemmingerRenal Section, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Cole L MartinDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama.
Stephen G AllerRenal Section, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0003-0379-5534
John N ForrestRenal Section, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Mount Desert Island Biological Laboratory · USUniversity of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
THE EPITHELIA OF THE EYE--EFFECT OF ENVIRONMENTAL AGENTSP30ES003828 · NIEHS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI BOYER, JAMES LORENZEN · 1987 to 2008
$4.1M
ADENOSINE RECEPTORS AND ION TRANSPORT IN EPITHELIAR01DK034208 · NIDDK · YALE UNIVERSITY · PI FORREST, JOHN N · 1986 to 2003
$1.6M
NIDDK NIH HHS P30 DK072482NIDDK NIH HHS R01 DK034208NIEHS NIH HHS P30 ES003828
6 · The paper itself

Abstract

Adenosine receptors (ADORs) are G protein-coupled purinoceptors that have several functions including regulation of chloride secretion via cystic fibrosis transmembrane conductance regulator (CFTR) in human airway and kidney. We cloned an ADOR from

Indexed as

AnimalsChloridesCloning, MolecularCystic Fibrosis Transmembrane Conductance RegulatorEvolution, MolecularFemaleFish ProteinsHumansMaleMembrane PotentialsPhylogenyProtein ConformationPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsReceptors, Purinergic P1Salt GlandChloridesCystic Fibrosis Transmembrane Conductance RegulatorFish ProteinsPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsReceptors, Purinergic P1adenosine receptorCFTRchloride secretionmolecular evolutionsharkstructural biology

Identifiers

PMID33689481
PMCPMC8163574
OpenAlexW3134141314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.