Evidence map›Paper›PMID 33689479›Full record

ArticleAmerican journal of physiology. Cell physiology2021

Inhibition of P110α and P110δ catalytic subunits of PI3 kinase reverses impaired arterial healing after injury in hypercholesterolemic male mice.

Pinaki Chaudhuri, Andrew H Smith, Linda M Graham, Michael A Rosenbaum

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Coronary plaque healing: a safety net or a hazard indicator?Journal of thrombosis and thrombolysis · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pinaki ChaudhuriDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio.
Andrew H SmithDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio.
Linda M GrahamDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0003-0531-2153
Michael A RosenbaumSurgical Service, Louis B. Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio.ORCID 0000-0002-1760-9299
Cleveland Clinic · USLouis Stokes Cleveland VA Medical Center · US

Funding

EFFECT OF LIPIDS ON VASCULAR GRAFT HEALINGR01HL064357 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI GRAHAM, LINDA M · 2000 to 2021
$7.0M
Effect of Lipids on Vascular Graft HealingR56HL064357 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI GRAHAM, LINDA M · 2009 to 2009
$465k
Endothelial Healing is Inhibited by PI3 Kinase-Induced Activation of TRPC6IK2BX003628 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI ROSENBAUM, MICHAEL AARIC · 2017 to 2021
–
BLRD VA IK2 BX003628NHLBI NIH HHS R01 HL064357NHLBI NIH HHS R56 HL064357
6 · The paper itself

Abstract

Endothelial cell (EC) migration is critical for healing arterial injuries, such as those that occur with angioplasty. Impaired re-endothelialization following arterial injury contributes to vessel thrombogenicity, intimal hyperplasia, and restenosis. Oxidized lipid products, including lysophosphatidylcholine (lysoPC), induce canonical transient receptor potential 6 (TRPC6) externalization leading to increased [Ca

Indexed as

AnimalsCatalytic DomainCattleCell LineClass I Phosphatidylinositol 3-KinasesEndothelial CellsFemaleHumansHypercholesterolemiaMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProtein IsoformsSignal TransductionWound Healing1-phosphatidylinositol 3-kinase p110 subunit, mouseClass I Phosphatidylinositol 3-KinasesPhosphatidylinositol 3-KinasesProtein Isoformsarterial healingp110αp110δPI3-kinaseTRPC6

Identifiers

PMID33689479
PMCPMC8285636
OpenAlexW3135157162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.