ArticleESC heart failure2021
Continuous versus intermittent use of furosemide in patients with heart failure and moderate chronic renal dysfunction.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07464249 (Comparison of the Effectiveness of Bolus and Infusion Diuretic Therapy in the Management of Acute Heart Failure in Emergency Departments), which is not on this map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effectiveness of Bolus and Infusion Diuretic Therapy in the Management of Acute Heart Failure in Emergency Departments: a Randomised, Double-blind Clinical Study
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Diuretic strategies in acute heart failure: a systematic review and network meta-analysis of randomized clinical trials.European heart journal. Cardiovascular pharmacotherapy · 2026Pooled it
- Comparative efficacy of continuous versus intermittent administration of furosemide in acute heart failure: an updated systematic review and meta-analysis of 22 RCTs.Frontiers in cardiovascular medicine · 2026Pooled it
- Continuous infusion versus bolus injection of loop diuretics for acute heart failure.The Cochrane database of systematic reviews · 2024Pooled it
- Comparison of continuous loop diuretic versus bolus injection regimens in patients with heart failure: a comprehensive meta-analysis of the literature.Revista da Associacao Medica Brasileira (1992) · 2022Pooled it
- Comparison of Different Furosemide Regimens in the Treatment of Acute Heart Failure: A Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Review
- Diuretic therapy for critically ill patients: a systematic review and network meta-analysis.Annals of intensive care · 2026Article
- Review
- Novel Approaches in Chronic Renal Failure without Renal Replacement Therapy: A Review.Biomedicines · 2023Review
- Review
- Clinical Effect of Mudan Granule on Peripheral Neuritis Caused by Chronic Renal Insufficiency.Computational and mathematical methods in medicine · 2022Article
- Continuous versus intermittent use of furosemide in patients with heart failure and moderate chronic renal dysfunction.ESC heart failure · 2021Article
- Randomized comparison of continuous versus intermittent bolus furosemide in neonatal heart failure.Annals of pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThere is paucity of clinical data comparing continuous infusion (CI) with bolus injection (BI) of intravenous loop diuretics in patients with acute decompensated heart failure (ADHF) and chronic renal dysfunction. This study aimed to compare the efficacy and safety of CI versus BI intravenous furosemide administration in patients with ADHF and moderate chronic renal insufficiency. METHODS AND
resultsAcute decompensated heart failure and moderate chronic renal insufficiency [with estimated glomerular filtration rate (eGFR) 15.0-44.9 mL/min/1.73 m
conclusionsContinuous intravenous infusion of furosemide resulted in significantly greater diuresis than bolus administration of an equal dose in patients with moderate chronic renal insufficiency and ADHF, while no differences emerged in terms of side effects or mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.