Observational studyESC heart failure2021
Resource utilization and costs among patients with heart failure with reduced ejection fraction following a worsening heart failure event.
Observational study in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Long-term clinical outcomes and healthcare resource utilization in male and female patients following hospitalization for heart failure.European journal of heart failure · 2025Trial
- Cost-effectiveness of a pictorial medication sheet for older adults with heart failure and cognitive impairment.BMC health services research · 2026Article
- Changes in health insurance status and mortality in patients with acute heart failure.American heart journal plus : cardiology research and practice · 2025Article
- Real-World Clinical Outcomes and Health Care Utilization in Patients With Severe Tricuspid Regurgitation.Structural heart : the journal of the Heart Team · 2025Article
- Days Not at Home: Association of Vulnerability with Healthcare Utilization After Hospitalization for Heart Failure.Journal of general internal medicine · 2025Article
- Worsening Heart Failure and Medication Use in HFrEF: A Finnish Retrospective Registry Study and Patient Survey.International journal of heart failure · 2025Article
- Increasing Readmissions of HFpEF and the Burden They Cause.International journal of heart failure · 2025Article
- Data Mining to Identify the Right Interventions for the Right Patient for Heart Failure: A Real-World Study.Healthcare informatics research · 2025Article
- Primary Causes and Direct Medical Cost of Heart Failure Among Adults Admitted with Acute Decompensated Heart Failure in a Public Tertiary Hospital, Kenya.Global heart · 2025Article
- Associations between Physical Activity, Systemic Inflammation, and Hospital Admissions in Adults with Heart Failure.Cardiopulmonary physical therapy journal · 2024Article
- Cost-utility of cardiac contractility modulation in patients with heart failure with reduced ejection fraction in Italy.ESC heart failure · 2024Article
- Evolution of economic burden of heart failure by ejection fraction in newly diagnosed patients in Spain.BMC health services research · 2023Article
- Risk factors of readmission and the impact of outpatient management in heart failure patients: A national study in Japan.ESC heart failure · 2023Article
- Successes and challenges of artificial intelligence in cardiology.Frontiers in digital health · 2023Review
- Financial burden of heart failure in Malaysia: A perspective from the public healthcare system.PloS one · 2023Article
- Cost analysis of chronic heart failure management in Malaysia: A multi-centred retrospective study.Frontiers in cardiovascular medicine · 2022Article
- Resource utilization and costs among patients with heart failure with reduced ejection fraction following a worsening heart failure event.ESC heart failure · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study is to characterize healthcare resource utilization and costs in patients with heart failure with reduced ejection fraction (HFrEF) following a worsening heart failure event. METHODS AND
resultsThis was a retrospective observational cohort analysis. Patients with HFrEF were identified from the PINNACLE Registry and linked to a nationwide pharmacy and medical claims database. Worsening heart failure was defined as stable heart failure with a subsequent hospitalization and/or intravenous diuretic therapy. Healthcare resource use and costs in 2015 US dollars were analysed for dispensed prescriptions, outpatient encounters, and hospital encounters. Among 11 064 patients with HFrEF, 3087 (27.9%) experienced a worsening heart failure event during an average follow-up of 973 days. During the first 30 days after the worsening event, 19.8% of patients had hospital readmissions with heart failure as the primary or secondary diagnosis. During that same time period, mean per patient heart failure-related healthcare resource use included 1.3 prescriptions, 0.5 practitioner visits, and 0.5 hospital encounters (admissions, observations, or emergency care), for an average total medical cost of $8779 per patient including $5359 in heart failure-related costs. During the first year following worsening heart failure onset, mean per patient total and heart failure-related costs were $62 615 and $35 329, respectively.
conclusionsThe economic burden following a worsening heart failure event calls for further review of methods to prevent progressive disease, improve adherence to guideline-directed therapy, and develop novel treatments and care strategies to moderate further progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.