Evidence map›Paper›PMID 33689074›Full record

ArticleDoklady. Biochemistry and biophysics2021

Thermovaccination: Thermoheliox as an Immune Response Stimulant. Kinetics of Antibodies and C-Reactive Protein Synthesis in Coronaviral Infection.

S D Varfolomeev, S V Zhuravel, A A Panin, L V Shogenova, V I Bykov, S B Tsybenova, A M Ryabokon, I I Utkina, P V Gavrilov, A G Chuchalin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

S D VarfolomeevDepartment of Chemistry, Moscow State University, 119991, Moscow, Russia.
S V ZhuravelSklifosovsky Federal Research Institute of Emergency Medicine, Moscow, Russia.
A A PaninOOO MedTechInnovations, Moscow, Russia.
L V ShogenovaPirogov Russian State National Research Medical University, Moscow, Russia.
V I BykovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
S B TsybenovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. s.tsybenova@gmail.com.
A M RyabokonEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
I I UtkinaSklifosovsky Federal Research Institute of Emergency Medicine, Moscow, Russia.
P V GavrilovSklifosovsky Federal Research Institute of Emergency Medicine, Moscow, Russia.
A G ChuchalinPirogov Russian State National Research Medical University, Moscow, Russia.
Institute of Biochemical Physics NM Emanuel · RUResearch Institute of Emergency Care · RUPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high efficiency of using thermoheliox (inhalation with a high-temperature mixture of helium and oxygen) in the treatment of patients affected by COVID-19 was shown. The dynamics of accumulation of IgG, IgM, and C-reactive protein (CRP) in patients with coronavirus infection in the "working" and control groups was studied experimentally. It was shown that thermoheliox intensifies the synthesis of IgG, IgM, and CRP antibodies, while eliminating the induction period on the kinetic curves of the synthesis of specific antibodies in the IgG form and transfers the synthesis of CRP to a fast phase. The results of experiments confirm the previously obtained data based on the analysis of the kinetic model of the development of coronaviral infection in the human body.

Indexed as

Antibodies, ViralCOVID-19C-Reactive ProteinHumansImmunityKineticsSpike Glycoprotein, CoronavirusVaccinationAntibodies, ViralC-Reactive ProteinSpike Glycoprotein, CoronaviruscoronavirusC-reactive proteinimmunoglobulin Gimmunoglobulin Mkinetic modelthermohelioxthermovaccination

Identifiers

PMID33689074
PMCPMC7944475
OpenAlexW3135865185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.