Evidence map›Paper›PMID 33689063›Full record

Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome.

Emily C Smith, Jorge Celedonio, Victor C Nwazue, Emily M Garland, Sachin Y Paranjape, Abby H Chopoorian, Amr Wahba, Italo Biaggioni, Bonnie Black, Cyndya A Shibao and 4 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01550315 (A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01550315 nacompletednot on this map

A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium

TypeinterventionalSponsorVanderbilt University Medical CenterRan2012 to 2021Enrolled27ConditionsPostural Tachycardia Syndrome (POTS)ArmsPulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Emily C SmithDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.ORCID 0000-0002-5078-6748
Jorge CeledonioDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Victor C NwazueDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Emily M GarlandDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Sachin Y ParanjapeDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Abby H ChopoorianVanderbilt University School of Medicine, Nashville, TN, USA.
Amr WahbaDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Italo BiaggioniDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Bonnie BlackDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Cyndya A ShibaoDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
André DiedrichDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Luis E OkamotoDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Satish R RajDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA.
Alfredo GamboaDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 560A RRB, 2222 Pierce Ave,, Nashville, TN, 37232, USA. alfredo.gamboa@vanderbilt.edu.
Vanderbilt University Medical Center · USVanderbilt University · USUniversity of Calgary · CA

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 1997 to 2016
$30.8M
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of ObesityR01HL149386 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2019 to 2023
$3.0M
Aldosterone and Sodium Regulation in Postural Tachycardia SyndromeR01HL102387 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GARLAND, EMILY M · 2010 to 2014
$2.1M
Autonomic Determinants of Postural Tachycardia SyndromeR01HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2019 to 2022
$1.7M
Autonomic Determinants of Postural Tachycardia SyndromeR56HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2018 to 2018
$391k
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS P01 HL056693NHLBI NIH HHS R01 HL102387NHLBI NIH HHS R01 HL142583NHLBI NIH HHS R01 HL149386NHLBI NIH HHS R56 HL142583
6 · The paper itself

Abstract

purposePostural tachycardia syndrome (POTS), a syndrome characterized by orthostatic symptoms and a heart rate increase of at least 30 beats per minute in the absence of hypotension upon standing, is often accompanied by increased sympathetic activity and low blood volume. A common non-pharmacologic recommendation for patients with POTS is a high-sodium (HS) diet with the goal of bolstering circulating blood volume. The objective of this study is to assess the effects of 6 days of a HS diet on endothelial function in POTS.

methodsA total of 14 patients with POTS and 13 age-matched healthy controls, all females, were studied following 6 days on a low-sodium (LS) diet (10 mEq/day) and 6 days on a HS diet (300 mEq/day) in a crossover design. We measured endothelial function following reactive hyperemia in the brachial artery using flow-mediated dilation (FMD), leg blood flow (LBF) using strain gauge plethysmography in the calf, and reactive hyperemic index (RHI) in the microcirculation of the hand using pulsatile arterial tonometry.

resultsOn the LS diet, FMD% did not differ between patients with POTS and the healthy controls although peak brachial artery diameter was lower for the patient group. RHI was higher for the patient group than for the controls, but there were no differences in post-ischemic LBF increase. On the HS diet, there were no between-group differences in FMD%, LBF increase, or RHI.

conclusionIn summary, a HS diet for 6 days did not induce endothelial dysfunction. This non-pharmacologic treatment used for patients with POTS does not negatively affect endothelial function when used for a sub-acute duration.

trial registrationClinicalTrials.gov NCT01550315; March 9, 2012.

Indexed as

Postural Orthostatic Tachycardia SyndromeBlood PressureCross-Over StudiesDietFemaleHeart RateHumansSodiumSodiumAutonomic nervous systemDietary saltEndothelial functionNitric oxidePostural tachycardia syndrome

Identifiers

PMID33689063
PMCPMC8295180
OpenAlexW3134840907

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.