Observational studyClinical and experimental nephrology2021
Association between serum uric acid and new onset and progression of chronic kidney disease in a Japanese general population: Iki epidemiological study of atherosclerosis and chronic kidney disease.
Observational study in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Alcohol consumption and the incidence of hyperuricemia in Japanese men and women.Scientific reports · 2026Article
- Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia.Scientific reports · 2025Article
- Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study.Scientific reports · 2025Article
- Relationship between abdominal circumference and the incidence of hyperuricemia in the general Japanese population.Scientific reports · 2024Article
- Hyperuricemia and associated factors: The case of outpatients at the Bafoussam Regional Hospital- Cameroon, an analytical cross-sectional study.Health science reports · 2024Article
- Alterations of gut microbiota and metabolome in early chronic kidney disease patients complicated with hyperuricemia.Heliyon · 2023Article
- Association of blood pressure and hyperuricemia with proteinuria and reduced renal function in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- The Bidirectional Relationship between Chronic Kidney Disease and Hyperuricemia: Evidence from a Population-Based Prospective Cohort Study.International journal of environmental research and public health · 2023Article
- Association between serum uric acid and arterial stiffness in a large-aged 40-70 years old population.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Evaluation of the Effect of Topiroxostat on Renal Function in Patients with Hyperuricemia: STOP-C Study, a Retrospective Observational Cohort Study.Drugs - real world outcomes · 2022Article
- Prediction of chronic kidney disease after orthotopic liver transplantation: development and validation of a nomogram model.BMC nephrology · 2022Article
- The Association between Baseline, Changes in Uric Acid, and Renal Failure in the Elderly Chinese Individuals: A Prospective Study with a 3-Year Follow-Up.International journal of endocrinology · 2022Article
- Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough several risk factors for chronic kidney disease (CKD) have been proposed, it remains unclear whether elevated serum uric acid (SUA) is negatively association with kidney function. The aim of this study was to elucidate the association between SUA and new onset and progression of CKD in a Japanese general population.
methodsThis was a population-based retrospective cohort study using annual health checkup data of residents of Iki Island. A total of 5,507 adults (979 with CKD and 4,528 without) were included. The outcomes were new onset of CKD among participants without CKD at baseline, and progression of CKD among those with CKD. A Cox proportional hazards model was used to evaluate the association between SUA and new onset and progression of CKD.
resultsDuring mean follow-up of 4.6 years, 757 cases of new onset of CKD and 193 with progression of CKD were observed. SUA was significantly associated with new onset of CKD (adjusted hazard ratio 1.13, [95% confidence interval 1.03-1.24] per standard deviation [SD] increase in SUA). In contrast, SUA was not significantly associated with progression of CKD (hazard ratio 1.08, [0.92-1.27] per SD increase). Similar results were obtained when classifying uric acid as categorical.
conclusionSUA was significantly associated with increased risk for new onset of CKD, but not with progression of CKD among a Japanese general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.