ArticleAnnals of intensive care2021
Early combination of albumin with crystalloids administration might be beneficial for the survival of septic patients: a retrospective analysis from MIMIC-IV database.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure.Hepatology international · 2024Guideline
- Construction and evaluation of neonatal respiratory failure risk prediction model for neonatal respiratory distress syndrome.BMC pulmonary medicine · 2024Trial
- Identifying a Refractory Shock Phenotype in Pediatric Sepsis Using a Vasoactive-Adjusted Shock Index.Shock (Augusta, Ga.) · 2026Article
- Association of Albumin Infusion With Differential Response in Pediatric Sepsis and Septic Shock: Retrospective Analysis Using a U.S. Multicenter 2012-2018 Dataset.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Article
- Early albumin infusion and mortality in ICU patients with HFpEF: a target trial emulation study.European journal of clinical pharmacology · 2026Article
- Blood urea nitrogen to albumin ratio and mortality in critically ill patients with cardiogenic shock.PloS one · 2026Article
- Albumin administration and 28-day mortality in sepsis-induced myocardial injury: a propensity score-matched analysis.Frontiers in pharmacology · 2026Article
- Discontinuation of Renin-Angiotensin System Inhibitors during Acute Kidney Injury Episode and All-Cause Mortality: Target Trial Emulation Studies.Journal of the American Society of Nephrology : JASN · 2025Article
- Early use of albumin may increase the risk of sepsis-associated acute kidney injury in sepsis patients: a target trial emulation.Military Medical Research · 2025Article
- Red cell distribution width and clinical outcomes in sepsis patients infected with Escherichia coli using data from MIMIC-IV.European journal of medical research · 2025Article
- Predicting infections with multidrug-resistant organisms (MDROs) in neurocritical care patients with hospital-acquired pneumonia (HAP): development of a novel multivariate prediction model.Microbiology spectrum · 2025Article
- Step-by-step causal analysis of EHRs to ground decision-making.PLOS digital health · 2025Article
- Article
- Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients.PloS one · 2025Article
- Machine learning algorithm for predict the in-hospital mortality in critically ill patients with congestive heart failure combined with chronic kidney disease.Renal failure · 2024Article
- The Indian Society of Critical Care Medicine Position Statement on the Management of Sepsis in Resource-limited Settings.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- ISCCM Position Statement: Management of Severe Dengue in Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Development and application of a risk nomogram for the prediction of risk of carbapenem-resistant Acinetobacter baumannii infections in neuro-intensive care unit: a mixed method study.Antimicrobial resistance and infection control · 2024Article
- Development and validation of a nomogram for predicting in-hospital death in cirrhotic patients with acute kidney injury.BMC nephrology · 2024Article
- Association between glycemic variability and short-term mortality in patients with acute kidney injury: a retrospective cohort study of the MIMIC-IV database.Scientific reports · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFluid therapy is a cornerstone in the treatment of sepsis. Recently, the guidelines have recommended the combined administration that using crystalloids plus albumin for septic patients, but the optimal timing for albumin combined is still unclear. The objective of this study was to investigate the association of timing of albumin combined with 28-day mortality in patients with sepsis.
methodsWe involved septic patients from the Medical Information Mart for Intensive Care (MIMIC)-IV database, and these patients were categorized into crystalloids group (crystalloids alone) and early combination group (crystalloids combined albumin at 0-24 h). The primary outcome was 28-day mortality. We used propensity score matching (PSM) to adjust confounding and restricted mean survival time (RMST) analysis was conducted to quantify the beneficial effect on survival due to the combination group.
resultsWe categorized 6597 and 920 patients in the "crystalloids alone" and "early combination", respectively. After PSM, compared to the crystalloids group, the combination group was associated with the increased survival among 28-day (increased survival: 3.39 days, 95% CI 2.53-4.25; P < 0.001) after ICU admission. Patients who received albumin combination at the first 24-h was associated with prolonged LOS in ICU (10.72 days vs. 8.24 days; P < 0.001) but lower risk of 28-day mortality (12.5% vs 16.4%, P = 0.003) than those received crystalloids alone.
conclusionIn septic patients, receiving albumin combined within the first 24-h after crystalloids administration was associated with an increment of survival in 28 days.
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