ArticleEuropean child & adolescent psychiatry2022
Early signs of autism in infants whose mothers suffered from a threatened preterm labour: a 30-month prospective follow-up study.
Article in European child & adolescent psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Association between gut microbiota and psychiatric disorders: a systematic review.Frontiers in psychology · 2023Pooled it
- Executive function development between ages 2 and 6 in children exposed to threatened preterm labor.European child & adolescent psychiatry · 2026Article
- Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol.BMJ open · 2024Article
- Temperamental and psychomotor predictors of ADHD symptoms in children born after a threatened preterm labour: a 6-year follow-up study.European child & adolescent psychiatry · 2023Article
- Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System.Fetal diagnosis and therapy · 2023Article
- Towards Robot-Assisted Therapy for Children With Autism-The Ontological Knowledge Models and Reinforcement Learning-Based Algorithms.Frontiers in robotics and AI · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Infants born after a threatened preterm labour (TPL infants) are at high risk of autism spectrum disorder (ASD). Studying this population may provide insight on the pathophysiological underpinnings of this condition. This study aimed to (i) ascertain the presence and autistic symptom load in TPL infants aged age 30 months relative to non-TPL infants, regardless of preterm birth; (ii) explore the association between early (at 6 months) psychomotor development and temperament features with the autistic symptom load of TPL infants at age 30 months and (iii) examine the association among perinatal risk factors for ASD development with the autistic symptom load of TPL infants at age 30 months. A group of 111 mother-infant pairs recruited at TPL diagnosis and a group of 47 healthy mother-infant controls completed the follow-up. Irrespective of preterm birth, TPL infants showed higher autistic symptom load at age 30 months than non-TPL infants. TPL infants presented poorer communication and problem-solving skills, reduced smiling and laughter, and greater vocal reactivity at age 6 months, predicting higher autistic symptom load at age 30 months. Higher levels of anxiety symptoms in TPL mothers after a TPL diagnosis also predicted higher autistic symptom load for the infants at age 30 months. These results suggest that TPL infants may be an undescribed cluster, with features that differentiate them from other "at-risk" populations. These findings support the need for routine assessment of TPL infants and screening of anxiety symptoms in mothers.
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