Evidence map›Paper›PMID 33688985›Full record

ArticleAbdominal radiology (New York)2021

Moozhan Nikpanah, Anna K Paschall, Mark A Ahlman, Ali Cahid Civelek, Faraz Farhadi, S Mojdeh Mirmomen, Xiaobai Li, Babak Saboury, Mark W Ball, Maria J Merino and 4 more

Open access · greenAbstract read
In one paragraph

Article in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Moozhan NikpanahRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Anna K PaschallDuke University School of Medicine, Durham, NC, USA.
Mark A AhlmanRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Ali Cahid CivelekDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Faraz FarhadiRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
S Mojdeh MirmomenAdvanced Cardiovascular Imaging Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Xiaobai LiBiostatistics and Epidemiology, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Babak SabouryRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Mark W BallUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Maria J MerinoLaboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ramaprasad SrinivasanUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Elizabeth C JonesRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
W Marston LinehanUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. linehanm@mail.nih.gov.
Ashkan A MalayeriRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA. ashkan.malayeri@nih.gov.ORCID 0000-0002-4442-7343
National Institutes of Health Clinical Center · USNational Institutes of Health · USDartmouth College · USDuke University · USJohns Hopkins University · US

Funding

Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase GeneZIABC011038 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$29.8M
Molecular Therapeutics of Kidney Cancer: MET Gene and BHD GeneZIABC011043 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$20.9M
Clinical Studies of the Molecular Genetic Basis of Kidney CancerZIABC011028 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$17.9M
Clinical Nursing and Data Management CoreZIDBC011089 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$17.4M
Targeting Genetic and Metabolic Alterations in Distinct Subtypes of RCCZIABC011648 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SRINIVASAN, RAMAPRASAD · 2015 to 2025
$12.2M
Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

purposeTo assess differences in FDG-PET/CT uptake among four subtypes of renal tumors: clear cell RCC (ccRCC), papillary type I and II RCC (pRCC), and oncocytoma.

methodsThis retrospective study investigated 33 patients with 98 hereditary renal tumors. Lesions greater than 1 cm and patients with a timeframe of less than 18 months between preoperative imaging and surgery were considered. FDG-PET/CT images were independently reviewed by two nuclear medicine physicians, blinded to clinical information. Volumetric lesion SUV

resultsThe time interval between imaging and surgery for all tumors had a median of 77 (Mean: 139; Range: 1-512) days. Intra-class reliability of mean TBR resulted in a mean κ score of 0.93, indicating strong agreement between the readers. The mixed model showed a significant difference in mean TBR among the subtypes (p < 0.0001). Pairwise comparison showed significant differences between pRCC type II and ccRCC (p < 0.0001), pRCC type II and pRCC type I (p = 0.0001), and pRCC type II and oncocytoma (p = 0.0016). Furthermore, a significant difference in FDG uptake was present between primary pRCC type II renal lesions with and without distant metastasis (p = 0.023).

conclusionpRCC type II lesions demonstrated significantly higher FDG activity than ccRCC, pRCC type I, or oncocytoma. These findings indicate that FDG may prove useful in studying the metabolic activity of renal neoplasms, identifying lesions of highest clinical concern, and ultimately optimizing active surveillance, and personalizing management plans.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsCell DifferentiationFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyReproducibility of ResultsRetrospective StudiesFluorodeoxyglucose F1818FDG-PET/CTHereditary Kidney Cancer SyndromesRenal tumorsSubtype differentiation

Identifiers

PMID33688985
PMCPMC9389933
OpenAlexW3135541591

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.