Trial reportJournal of medical Internet research2021
Online Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth With Major Depressive Disorders: Randomized Controlled Trial.
Trial report in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 22 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Innovative Smartphone-enabled Health Coaching Intervention for Youth Diagnosed With Major Depressive Disorders
A Remote Electronically Delivered Integrated Care Pathway for Adolescents With Major Depressive Disorder: A Feasibility Study
Efficacy of an Online Mindfulness-based Cognitive Skills Program on Depressive Symptoms and Quality of Life in University Students
Efficacy of Mindfulness-cognitive Oriented Group Intervention Program on Depressive Symptoms, Coping Strategies and Quality of Life in University Students
Evaluating the Effectiveness of an Online 6-weeks Mindfulness-Based Cognitive Therapy in Depressed Sample: a Randomized Three-arm Clinical Trial
Who cites it
22 citing papers in PubMed, 7 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The Influence of eHealth Stress Management Interventions on Psychological Health Parameters in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- The effectiveness of telemedicine applications in mental health services: a meta-analysis study.Irish journal of medical science · 2025Pooled it
- Digital Psychotherapies for Adults Experiencing Depressive Symptoms: Systematic Review and Meta-Analysis.JMIR mental health · 2024Pooled it
- Opportunities and challenges in leveraging digital technology for mental health system strengthening: a systematic review to inform interventions in the United Arab Emirates.BMC public health · 2024Pooled it
- Heterogeneity of Treatment Effects in Internet- and Mobile-Based Interventions for Depression: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Time-Dependent Changes in Depressive Symptoms Among Control Participants in Digital-Based Psychological Intervention Studies: Meta-analysis of Randomized Controlled Trials.Journal of medical Internet research · 2023Pooled it
- The efficacy of mindfulness-based interventions on mental health among university students: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- The application of a digital therapeutic reveals superior outcome compared to standard care in patients with anterior knee pain-a randomized controlled trial.Archives of orthopaedic and trauma surgery · 2025Trial
- Trial
- The Efficacy of Computerized Cognitive Behavioral Therapy for Depressive and Anxiety Symptoms in Patients With COVID-19: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Network and machine learning analysis of childhood trauma, mental health, and AI-based emotional support needs in adolescents from underdeveloped regions.BMC psychology · 2026Article
- Metabolic profiling reveals potential biomarkers and underlying signaling pathways involved in mindfulness-based cognitive therapy-improved adolescent depression symptoms.EXCLI journal · 2026Article
- Online mindfulness interventions in the care of people with physical and mental health conditions: a scoping review.BMJ open · 2025Article
- Smartphone dependence and its influence on physical and mental health.Frontiers in psychiatry · 2025Review
- The Use of Text Messaging as an Adjunct to Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder in Youth: Secondary Analysis.JMIR formative research · 2024Article
- Effect of a mindfulness-based cognitive behavior therapy intervention on occupational burnout among school teachers.Frontiers in psychiatry · 2024Article
- The Role of Daily Steps in the Treatment of Major Depressive Disorder: Secondary Analysis of a Randomized Controlled Trial of a 6-Month Internet-Based, Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth.Interactive journal of medical research · 2023Article
- Understanding Mobile Health and Youth Mental Health: Scoping Review.JMIR mHealth and uHealth · 2023Article
- Personalization strategies in digital mental health interventions: a systematic review and conceptual framework for depressive symptoms.Frontiers in digital health · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundApproximately 70% of mental health disorders appear prior to 25 years of age and can become chronic when ineffectively treated. Individuals between 18 and 25 years old are significantly more likely to experience mental health disorders, substance dependencies, and suicidality. Treatment progress, capitalizing on the tendencies of youth to communicate online, can strategically address depressive disorders.
objectiveWe performed a randomized controlled trial (RCT) that compared online mindfulness-based cognitive behavioral therapy (CBT-M) combined with standard psychiatric care to standard psychiatric care alone in youth (18-30 years old) diagnosed with major depressive disorder.
methodsForty-five participants were randomly assigned to CBT-M and standard care (n=22) or to standard psychiatric care alone (n=23). All participants were provided standard psychiatric care (ie, 1 session per month), while participants in the experimental group received an additional intervention consisting of the CBT-M online software program. Interaction with online workbooks was combined with navigation coaching delivered by phone and secure text messaging.
resultsIn a two-level linear mixed-effects model intention-to-treat analysis, significant between-group differences were found for the Beck Depression Inventory-II score (difference -8.54, P=.01), Quick Inventory of Depressive Symptoms score (difference -4.94, P=.001), Beck Anxiety Inventory score (difference -11.29, P<.001), and Brief Pain Inventory score (difference -1.99, P=.03), while marginal differences were found for the Five Facet Mindfulness Questionnaire-Nonjudging subscale (difference -2.68, P=.05).
conclusionsThese results confirm that youth depression can be effectively treated with online CBT-M that can be delivered with less geographic restriction.
trial registrationClinical Trials.gov NCT03406052; https://www.clinicaltrials.gov/ct2/show/NCT03406052.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.