Evidence map›Paper›PMID 33688682›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Obesity is associated with an altered baseline and post-vaccination influenza antibody repertoire.

Marwa Abd Alhadi, Lilach M Friedman, Erik A Karlsson, Liel Cohen-Lavi, Anat Burkovitz, Stacey Schultz-Cherry, Terry L Noah, Samuel S Weir, Lester M Shulman, Melinda A Beck and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Marwa Abd AlhadiDepartment of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.
Lilach M FriedmanDepartment of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.
Erik A KarlssonVirology Unit, Institute Pasteur du Cambodge; Phnom Penh, Cambodia.
Liel Cohen-LaviNational Center for Biotechnology in the Negev, Ben-Gurion University of the Negev; Beer-Sheva, Israel.
Anat BurkovitzDepartment of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital; Memphis, TN, USA.
Terry L NoahDepartment of Pediatrics, University of North Carolina at Chapel Hill; NC, USA.
Samuel S WeirDepartment of Family Medicine, University of North Carolina at Chapel Hill; NC, USA.
Lester M ShulmanDept. of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University; Tel Aviv, Israel.
Melinda A BeckDepartment of Nutrition, Gillings School of Global Public Health, UNC, Chapel Hill; NC, USA.
Tomer HertzDepartment of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.

Funding

Risk of Influenza Infection In A Vaccinated Obese PopulationR01AI078090 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BECK, MELINDA A. · 2009 to 2016
$4.5M
NIAID NIH HHS R01 AI078090
6 · The paper itself

Abstract

As highlighted by the ongoing COVID-19 pandemic, vaccination is critical for infectious disease prevention and control. Obesity is associated with increased morbidity and mortality from respiratory virus infections. While obese individuals respond to influenza vaccination, what is considered a seroprotective response may not fully protect the global obese population. In a cohort vaccinated with the 2010-2011 trivalent inactivated influenza vaccine, baseline immune history and vaccination responses were found to significantly differ in obese individuals compared to healthy controls, especially towards the 2009 pandemic strain of A/H1N1 influenza virus. Young, obese individuals displayed responses skewed towards linear peptides versus conformational antigens, suggesting aberrant obese immune response. Overall, these data have vital implications for the next generation of influenza vaccines, and towards the current SARS-CoV-2 vaccination campaign.

Identifiers

PMID33688682
PMCPMC7941659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.