Evidence map›Paper›PMID 33688663›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Just 2% of SARS-CoV-2-positive individuals carry 90% of the virus circulating in communities.

Qing Yang, Tassa K Saldi, Erika Lasda, Carolyn J Decker, Camille L Paige, Denise Muhlrad, Patrick K Gonzales, Morgan R Fink, Kimngan L Tat, Cole R Hager and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 35 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Qing YangBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Tassa K SaldiBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Erika LasdaBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Carolyn J DeckerDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Camille L PaigeBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Denise MuhlradDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Patrick K GonzalesBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Morgan R FinkBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Kimngan L TatBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Cole R HagerBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Jack C DavisDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Christopher D OzeroffBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Nicholas R MeyersonBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Stephen K ClarkBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Will T FattorBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Alison R GilchristBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Arturo Barbachano-GuerreroBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Emma R Worden-SapperBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Sharon S WuBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Gloria R BrissonWardenburg Health Center, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Matthew B McQueenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Robin D DowellBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Leslie LeinwandBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Roy ParkerBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
Sara L SawyerBioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
University of Colorado Boulder · USHoward Hughes Medical Institute · US

Funding

MYOSIN GENE DIVERSITY AND FUNCTIONR01GM029090 · NIGMS · YESHIVA UNIVERSITY · PI Leslie Anne Leinwand · 1985 to 2026
$12.3M
Hunting the HIV-1 UnicornDP1DA046108 · NIDA · UNIVERSITY OF COLORADO · PI SAWYER, SARA · 2018 to 2022
$4.5M
NIDA NIH HHS DP1 DA046108NIGMS NIH HHS R01 GM029090
6 · The paper itself

Abstract

We analyze data from the Fall 2020 pandemic response efforts at the University of Colorado Boulder (USA), where more than 72,500 saliva samples were tested for SARS-CoV-2 using quantitative RT-PCR. All samples were collected from individuals who reported no symptoms associated with COVID-19 on the day of collection. From these, 1,405 positive cases were identified. The distribution of viral loads within these asymptomatic individuals was indistinguishable from what has been previously reported in symptomatic individuals. Regardless of symptomatic status, approximately 50% of individuals who test positive for SARS-CoV-2 seem to be in non-infectious phases of the disease, based on having low viral loads in a range from which live virus has rarely been isolated. We find that, at any given time, just 2% of individuals carry 90% of the virions circulating within communities, serving as viral "super-carriers" and possibly also super-spreaders.

Identifiers

PMID33688663
PMCPMC7941634
OpenAlexW3134387616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.