Evidence map›Paper›PMID 33688611›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2021

Cytosolic PSD-95 interactor alters functional organization of neural circuits and AMPA receptor signaling independent of PSD-95 binding.

Ana R Rodriguez, Erin D Anderson, Kate M O'Neill, Przemyslaw P McEwan, Nicholas F Vigilante, Munjin Kwon, Barbara F Akum, Tamara M Stawicki, David F Meaney, Bonnie L Firestein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ana R RodriguezDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID https://orcid.org/0000-0002-2591-9393
Erin D AndersonDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-0575-6707
Kate M O'NeillDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID https://orcid.org/0000-0003-4397-5767
Przemyslaw P McEwanDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID https://orcid.org/0000-0002-7702-070X
Nicholas F VigilanteDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-0540-4816
Munjin KwonDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Barbara F AkumDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Tamara M StawickiDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID https://orcid.org/0000-0003-2191-8550
David F MeaneyDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-0954-4122
Bonnie L FiresteinDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID https://orcid.org/0000-0002-1679-3565
Rutgers, The State University of New Jersey · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytosolic PSD-95 interactor (cypin) regulates many aspects of neuronal development and function, ranging from dendritogenesis to synaptic protein localization. While it is known that removal of postsynaptic density protein-95 (PSD-95) from the postsynaptic density decreases synaptic N-methyl-D-aspartate (NMDA) receptors and that cypin overexpression protects neurons from NMDA-induced toxicity, little is known about cypin's role in AMPA receptor clustering and function. Experimental work shows that cypin overexpression decreases PSD-95 levels in synaptosomes and the PSD, decreases PSD-95 clusters/μm

Indexed as

AMPA receptorsCypinElectrophysiologyHippocampal neuronsMicroelectrode arrayNeural circuits

Identifiers

PMID33688611
PMCPMC7935033
OpenAlexW3096712346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.