ArticleNetwork neuroscience (Cambridge, Mass.)2021
Dynamic community detection reveals transient reorganization of functional brain networks across a female menstrual cycle.
Article in Network neuroscience (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06910293 (Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation
Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial.Translational psychiatry · 2023Trial
- Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.Biological psychiatry global open science · 2026Review
- Triple Network Neuroplasticity and Perinatal Mood Symptoms from Preconception to Postpartum: A Pilot Study.Journal of clinical medicine · 2026Article
- Dense longitudinal neuroimaging reveals individual brain change trajectories.Trends in cognitive sciences · 2026Review
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- The lateral septum orchestrates state-dependent modulation of associative threat memory dynamics across the ovarian hormone cycle.bioRxiv : the preprint server for biology · 2026Article
- The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women.Communications biology · 2026Article
- A standardized non-linear approach to studying menstrual cycle effects on brain and behavior.Frontiers in cognition · 2026Article
- Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals.Nature neuroscience · 2025Article
- Estrogen-Mediated Neural Mechanisms of Sex Differences in Burning Mouth Syndrome.Neurology international · 2025Article
- Exploring neuroendocrine influences on the sensorimotor-association axis in a female and a male individual.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Idiosyncrasy and generalizability of contraceptive- and hormone-related functional connectomes across the menstrual cycle.Network neuroscience (Cambridge, Mass.) · 2025Article
- Functional brain connectivity changes associated with day-to-day fluctuations in affective states.Cognitive, affective & behavioral neuroscience · 2024Article
- Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Diurnal Fluctuations in Steroid Hormones Tied to Variation in Intrinsic Functional Connectivity in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Circadian rhythms tied to changes in brain morphology in a densely-sampled male.bioRxiv : the preprint server for biology · 2024Article
- Spotlighting SHAPERS: sex hormones associated with psychological and endocrine roles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Brain flexibility increases during the peri-ovulatory phase as compared to early follicular phase of the menstrual cycle.Scientific reports · 2024Article
- Brain fingerprint and subjective mood state across the menstrual cycle.Frontiers in neuroscience · 2024Article
- Looking Back to Move Forward: Research in Stress, Behavior, and Immune Function.Neuroimmunomodulation · 2024Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Sex steroid hormones have been shown to alter regional brain activity, but the extent to which they modulate connectivity within and between large-scale functional brain networks over time has yet to be characterized. Here, we applied dynamic community detection techniques to data from a highly sampled female with 30 consecutive days of brain imaging and venipuncture measurements to characterize changes in resting-state community structure across the menstrual cycle. Four stable functional communities were identified, consisting of nodes from visual, default mode, frontal control, and somatomotor networks. Limbic, subcortical, and attention networks exhibited higher than expected levels of nodal flexibility, a hallmark of between-network integration and transient functional reorganization. The most striking reorganization occurred in a default mode subnetwork localized to regions of the prefrontal cortex, coincident with peaks in serum levels of estradiol, luteinizing hormone, and follicle stimulating hormone. Nodes from these regions exhibited strong intranetwork increases in functional connectivity, leading to a split in the stable default mode core community and the transient formation of a new functional community. Probing the spatiotemporal basis of human brain-hormone interactions with dynamic community detection suggests that hormonal changes during the menstrual cycle result in temporary, localized patterns of brain network reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.