Evidence map›Paper›PMID 33688484›Full record

ArticleInternational journal of molecular and cellular medicine2020

The Expression Pattern and Clinicopathological Importance of Hsa_circ_000425 in Colorectal Cancer.

Davood Mohammadi, Ali Bastani, Yazdan Zafari, Sohrab Esmaealzadeh, Nafiseh Rastgou, Mohammad Bargahi, Sahar Moghbelinejad

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In one paragraph

Article in International journal of molecular and cellular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Davood MohammadiDepartment of Surgery, School of Medicine , Qazvin University of Medical Sciences, Qazvin, Iran.
Ali BastaniDepartment of Internal Medicine, School of Medicine , Qazvin University of Medical Sciences, Qazvin, Iran.
Yazdan ZafariDepartment of Hematology and Medical Oncology, School of Medicine , Qazvin University of Medical Sciences, Qazvin, Iran.
Sohrab EsmaealzadehSchool of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran .
Nafiseh RastgouSchool of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran .
Mohammad BargahiSchool of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran .
Sahar MoghbelinejadResearch Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre , Qazvin University of Medical Sciences, Qazvin, Iran.
Qazvin University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although colorectal cancer (CRC) is one of the most common cancers, the exact molecular mechanism of this cancer is not yet known. Circular RNAs (circRNAs), a class of non-coding RNAs, are newly identified and their role in the pathogenesis of various cancers has been shown. In this research, we studied the expression pattern and clinical importance of hsa_circ_000425 in CRC patients. After evaluation of hsa_circ_000425 expression rate in 4 CRC cell lines and 100 paired CRC tissues, the potential correlation between hsa_circ_000425 expression rate and clinicopathological parameters of CRC patients was analyzed. Additionally, receiver operating characteristic (ROC) curve was drawn to study the diagnostic value of hsa_circ_000425. A significant downregulation of hsa_circ_000425 was observed in both CRC tissues and cell lines. In addition, this downregulation was significantly associated with differentiation and lymphatic metastasis. The area under the ROC curve of hsa_circ_000425 was 0.839 (P < 0.001). hsa_circ_000425 may have a role in the pathogenesis of CRC and might act as a potential biomarker for the diagnosis and treatment of CRC; although further molecular studies must be performed in this regard.

Indexed as

Circular RNAcolorectal neoplasmhsa_circ_000425

Identifiers

PMID33688484
PMCPMC7936077
OpenAlexW3115772646

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.