Evidence map›Paper›PMID 33688422›Full record

ArticleJournal of healthcare engineering2021

Expression of Inflammatory Factors in Critically Ill Patients with Urosepticemia and the Imaging Analysis of the Severity of the Disease.

Xia Huang, Zongjun Hu, Xi Yue, Yong Cui, Jiwen Cui

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Journal of healthcare engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xia HuangDepartment of Critical Care Medicine Neurosurgery, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing 404000, China.
Zongjun HuDepartment of Critical Care Medicine Neurosurgery, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing 404000, China.
Xi YueDepartment of Critical Care Medicine Neurosurgery, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing 404000, China.
Yong CuiDepartment of Critical Care Medicine Neurosurgery, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing 404000, China.
Jiwen CuiDepartment of Critical Care Medicine Neurosurgery, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing 404000, China.ORCID 0000-0001-6541-9150
Chongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urine sepsis is a complex inflammatory response of the body to infection with a high fatality rate. It is one of the main causes of death in noncardiovascular intensive care units. Nevertheless, in daily clinical practice, early sepsis is often not detected. In this paper, discharged cases of urinary sepsis from the Department of Urology and Critical Care Medicine of a university hospital were collected as the observation group, and common urinary tract infection cases were selected as the control group. We sorted and summarized the discharged case information of the observation group and the control group. The results of the study showed that, after renal pelvis perfusion, the expression of HMGB1 protein and mRNA increased, and the expression of TLR4 increased; inhibiting HMGB1 can reduce the expression of inflammatory factors caused by perfusion and reduce the infiltration of neutrophils and macrophages caused by perfusion. In addition, r HMGB1 treatment can promote the expression of inflammatory factors caused by perfusion and aggravate the infiltration of neutrophils and macrophages caused by perfusion. We found that inhibition of HMGB1 can inhibit the expression of TLR4/My D88 signaling molecules and r HMGB1 treatment can enhance the expression of TLR4/My D88 signaling molecules.

Indexed as

HMGB1 ProteinSepsisCritical IllnessHumansKidneySignal TransductionToll-Like Receptor 4HMGB1 ProteinToll-Like Receptor 4

Identifiers

PMID33688422
PMCPMC7914102
OpenAlexW3131743567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.