Evidence map›Paper›PMID 33688389›Full record

ArticleOxidative medicine and cellular longevity2021

Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation.

Mauricio A Lillo, Pablo S Gaete, Mariela Puebla, Pía C Burboa, Inés Poblete, Xavier F Figueroa

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. The Expression Level of ABCC6 Transporter in Colon Cancer Cells Correlates with the Activation of Different Intracellular Signaling Pathways.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Article
  11. Pannexin1 channels-a potential therapeutic target in inflammation.Frontiers in cell and developmental biology · 2022
    Review
  12. Harmful and Beneficial Role of ROS 2020.Oxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mauricio A LilloDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.ORCID https://orcid.org/0000-0002-2823-6619
Pablo S GaeteDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.ORCID https://orcid.org/0000-0003-3373-9138
Mariela PueblaCentro de Fisiología Celular e Integrativa, Facultad de Medicina-Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.ORCID https://orcid.org/0000-0002-7756-2023
Pía C BurboaDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.ORCID https://orcid.org/0000-0002-4331-3336
Inés PobleteDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.
Xavier F FigueroaDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.ORCID https://orcid.org/0000-0001-9656-9100
Pontificia Universidad Católica de Chile · CLUniversidad del Desarrollo · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deletion of pannexin-1 (Panx-1) leads not only to a reduction in endothelium-derived hyperpolarization but also to an increase in NO-mediated vasodilation. Therefore, we evaluated the participation of Panx-1-formed channels in the control of membrane potential and [Ca

Indexed as

Signal TransductionVasodilationAnimalsArteriesCalcium ChannelsCalcium SignalingConnexinsEndothelial CellsMaleMembrane PotentialsNADPH OxidasesNerve Tissue ProteinsNitric OxideNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktCalcium ChannelsConnexinsNADPH OxidasesNerve Tissue ProteinsNitric OxideNitric Oxide Synthase Type IIIpannexin 1, ratProto-Oncogene Proteins c-aktSuperoxidesTetrodotoxin

Identifiers

PMID33688389
PMCPMC7914086
OpenAlexW3129332248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.