ArticleInternational journal of general medicine2021
Correlation Between Stress Scale and Serum Substance P Level in Acne Vulgaris.
Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Psychological Factors to Consider in Treating Patients with Acne Vulgaris.Journal of clinical medicine · 2026Review
- Sleep Disturbances and Acne: A Comprehensive Review.Dermatology practical & conceptual · 2025Review
- Impact of Stress on the Prevalence of Acne Among Medical Students in the Middle East: A Systematic Review.Cureus · 2025Review
- The impact of academic stress on acne: An observational cohort study among medical students in Morocco.JAAD international · 2025Article
- Significance of host antimicrobial peptides in the pathogenesis and treatment of acne vulgaris.Frontiers in immunology · 2024Review
- Proteomic and transcriptomic analyses ofAIMS microbiology · 2024Article
- Effectiveness of Standard Therapy for Acne Vulgaris Based on Clinical Practice Guidelines in Indonesia.Clinical, cosmetic and investigational dermatology · 2024Article
- Assessing Acne Severity: Teledermatology Versus Face to Face Consultations During the COVID-19 Pandemic.The Journal of clinical and aesthetic dermatology · 2023Article
- Article
- The increasing importance of the gut microbiome in acne vulgaris.Folia microbiologica · 2022Review
- Perceived stress in patients with inflammatory and non-inflammatory skin conditions. An observational controlled study among 255 Norwegian dermatological outpatients.Skin health and disease · 2022Article
- Cognitive, emotional, physical, and behavioral stress-related symptoms and coping strategies among university students during the third wave of COVID-19 pandemic.Frontiers in psychiatry · 2022Article
- The Association Between Short-Term Air Pollution Exposure and Post-Adolescent Acne: The Evidence from a Time Series Analysis in Xi'an, China.Clinical, cosmetic and investigational dermatology · 2021Article
- Correlation Between Stress Scale and Serum Substance P Level in Acne Vulgaris.International journal of general medicine · 2021Article
- Correlation between Antimicrobial ResistantIndian journal of dermatologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcne vulgaris is a chronic inflammatory disease of pilosebaceous follicles with polymorphic lesions, consisting of comedones, papules, pustules and nodules with varying degrees of severity. Stress is one of the triggers of acne vulgaris. Peripheral nerves release substance P in response to stress. Substance P causes proliferation and differentiation of sebaceous glands and increases lipid synthesis in sebocytes. PURPOSE: To determine the correlation between stress scale and serum substance P level in acne vulgaris. PATIENTS AND
methodsThis study was an observational analytic study with a cross-sectional design involving 30 patients with acne vulgaris and 30 controls. History taking, dermatological examination and the Holmes-Rahe stress scale questionnaire were performed with each patient to evaluate stress scale, followed by taking blood samples to assess substance P serum levels using the ELISA test. The collected data were analyzed using the Spearman correlation test.
resultsIn both groups, the majority of subjects were 23-27 years old (36.7%) and most of them were female (76.7%). The majority in the acne vulgaris group had low scores on the stress scale, represented by 17 patients (56.7%). The main cause of stress in the acne vulgaris group was a major change in sleeping habits (66.7%). In the acne vulgaris group, the highest mean value of serum substance P level in high stress scale group was 168.2 pg/mL. There was a positive correlation between stress scale and serum substance P level in acne vulgaris with moderate strength and this was statistically significant (r = 0.446; p = 0.014). Meanwhile, stress scale and serum substance P level in controls were not correlated and this was not statistically significant (r = -0.090; p = 0.636).
conclusionThere was a correlation between stress scale and serum substance P level in acne vulgaris.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.